Quantum mechanics predicts that certain stationary potentials can sustain bound states with an energy buried in the continuous spectrum of scattered states, the so-called bound states in the continuum (BIC). Originally regarded as mathematical curiosities, BIC have found an increasing interest in recent years, particularly in quantum and classical transport of matter and optical waves in mesoscopic and photonic systems where the underlying potential can be judiciously tailored. Most of our knowledge of BIC is so far restricted to static potentials. Here we introduce a new kind of BIC, referred to as Floquet BIC, which corresponds to a normalizable Floquet state of a time-periodic Hamiltonian with a quasienergy embedded into the spectrum of Floquet scattered states. We discuss the appearance of Floquet BIC states in a tight-binding lattice model driven by an ac field in the proximity of the dynamic localization regime.
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http://dx.doi.org/10.1038/srep02219 | DOI Listing |
EMBO J
January 2025
Department of Oncology, The University of Oxford, Oxford, OX3 7DQ, UK.
Hypoxia is a common feature of solid tumors that has previously been linked to resistance to radiotherapy and chemotherapy, and more recently to immunotherapy. In particular, hypoxic tumors exclude T cells and inhibit their activity, suggesting that tumor cells acquire a mechanism to evade T-cell recognition and killing. Our analysis of hypoxic tumors indicates that hypoxia downregulates the expression of MHC class I and its bound peptides (i.
View Article and Find Full Text PDFNat Struct Mol Biol
January 2025
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Transcription factors (TFs) recognize specific bases within their DNA-binding motifs, with each base contributing nearly independently to total binding energy. However, the energetic contributions of particular dinucleotides can deviate strongly from the additive approximation, indicating that some TFs can specifically recognize DNA dinucleotides. Here we solved high-resolution (<1 Å) structures of MYF5 and BARHL2 bound to DNAs containing sets of dinucleotides that have different affinities to the proteins.
View Article and Find Full Text PDFNat Commun
January 2025
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
WNT/β-catenin signaling plays key roles in development and cancer. ZNRF3/RNF43 modulates Frizzleds through ubiquitination, dampening WNT/β-catenin signaling. Conversely, RSPO1-4 binding to LGR4-6 and ZNRF3/RNF43 enhances WNT/β-catenin signaling.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA.
We investigate the thermoelectric response of an Abrikosov vortex in type-II superconductors in the deep quantum limit. We consider two thermoelectric geometries, a type-II superconductor-insulator-normal-metal (S-I-N) junction and a local scanning tunneling microscope (STM)-tip normal metal probe over the superconductor. We exploit the strong breaking of particle-hole symmetry in vortex-bound states at subgap energies within the superconducting vortex to realize a giant thermoelectric response in the presence of fluxons.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
European Synchrotron Radiation Facility (ESRF), 71 Avenue des Martyrs, Grenoble, CS 40220, 38043, France.
Studying the properties and phase diagram of iron at high-pressure and high-temperature conditions has relevant implications for Earth's inner structure and dynamics and the temperature of the inner core boundary (ICB) at 330 GPa. Also, a hexagonal-closed packed to body-centered cubic (bcc) phase transition has been predicted by many theoretical works but observed only in a few experiments. The recent coupling of high-power laser with advanced x-ray sources from synchrotrons allows for novel approaches to address these issues.
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