AI Article Synopsis
- The ALPHA hypothesis suggests that lactate helps create new blood vessels (vasculogenesis) to regulate its own levels in the body.
- This process supports existing ideas about how blood vessel formation occurs, particularly through the creation of drainage vessels.
- Initially, the focus is on forming lymphatic vessels, which later develop into veins.
Article Abstract
Our hypothesis, ALPHA (Acidic Lactate sequentially induced Lymphogenesis, PHlebogenesis, and Arteriogenesis) proposes that lactate triggers vasculogenesis to manage lactate levels and complements the traditional vasculogenesis hypothesis. The teleologic basis for glycolytic vasculogenesis is primariy to produce drainage vessels, initially lymphatics but subsequently veins.
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| http://dx.doi.org/10.1016/j.surg.2013.03.007 | DOI Listing |
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