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Comparative transcriptomic and molecular biology analyses to explore potential immune responses to challenge in .
Front Cell Infect Microbiol
December 2024
Phage Research Center of Liaocheng University, Liaocheng, China.
is a significant pathogen affecting shrimp and crab farming, particularly strains carrying genes associated with acute hepatopancreatic necrosis syndrome. However, the immune response of to infection remains unclear. To address this knowledge gap, an experiment was conducted to establish a infection model.
View Article and Find Full Text PDFAiming for precision: personalized medicine through sepsis subtyping.
Burns Trauma
January 2025
Amsterdam University Medical Center, University of Amsterdam, Center of Experimental and Molecular Medicine & Division of Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.
According to the latest definition, sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated host response to an infection. However, this definition fails to grasp the heterogeneous nature and the underlying dynamic pathophysiology of the syndrome. In response to this heterogeneity, efforts have been made to stratify sepsis patients into subtypes, either based on their clinical presentation or pathophysiological characteristics.
View Article and Find Full Text PDFTicks as vectors of Trypanosomatidae with medical or veterinary interest: Insights and implications from a comprehensive systematic review and meta-analysis.
Heliyon
December 2024
UMR INTERTRYP, IRD, CIRAD, University of Montpellier (I-MUSE), GoInsect: Infectiology and Entomology Research Group, Montpellier, France.
Since the 20th century, numerous studies have detected or isolated parasites from the Trypanosomatidae family in various tick species. However, the status of ticks as vectors for medically or veterinary significant and remains unclear. We conducted a systematic review and meta-analysis to provide new insights into the potential vector status of these pathogens, which have significant medical and veterinary implications.
View Article and Find Full Text PDFAdvanced deep transfer learning techniques for efficient detection of cotton plant diseases.
Front Plant Sci
December 2024
School of Information Technology (IT) and Engineering, Melbourne Institute of Technology, Melbourne, VIC, Australia.
Introduction: Cotton, being a crucial cash crop globally, faces significant challenges due to multiple diseases that adversely affect its quality and yield. To identify such diseases is very important for the implementation of effective management strategies for sustainable agriculture. Image recognition plays an important role for the timely and accurate identification of diseases in cotton plants as it allows farmers to implement effective interventions and optimize resource allocation.
View Article and Find Full Text PDFBivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice.
iScience
December 2024
Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Latent viral reservoirs (VRs) represent a main barrier to HIV cure. Thus, developing new approaches that can purge and eliminate VRs paves the path toward achieving an HIV-1 cure. APG-1387, a bivalent SMAC mimetic (SM), efficiently reactivates latent HIV expression in T cell line models and enhances active caspase 3 expression, a condition that typically leads to apoptosis.
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