Unlabelled: CONTEXT. Cymbopogon winterianus Jowitt ex Bor (Poaceae), known as citronella grass, is an aromatic herbaceous plant and the essential oil extracted from this grass is used in cosmetics, perfumes, hygiene and cleanliness products worldwide.
Objective: This study investigated the composition and molluscicidal and larvicidal activities of the essential oil of C. winterianus cultivated in North Brazil.
Materials And Methods: The oil was obtained by hydrodistillation, analyzed by gas chromatography (GC) and GC-mass spectrometry and then its molluscicidal and larvicidal activities against snails (Biomphalaria glabrata) and hatched larvae of Artemia salina, respectively, were evaluated at concentrations from 10 to 1000 mg/L.
Results: The main constituents of oil were citronellal (26.5%), geraniol (16.2%), elemol (14.5%) and citronellol (7.3%). The molluscicidal test revealed significant lethal concentration (LC) values (LC90=97.0 mg/L, LC50=54.0 mg/L and LC20=22.0 mg/L), indicating the presence of molluscicidal compounds in the oil. In addition, the oil showed moderate larvicidal activity (LC50=181.0 mg/L) against the larvae of A. salina, which could justify its use in the aquatic environment without affecting other living organisms.
Discussion And Conclusion: The results suggest that the oil of C. winterianus could be an effective alternative to control schistosomiasis, with an average margin of safety to other living organisms that coexist with snails.
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http://dx.doi.org/10.3109/13880209.2013.789536 | DOI Listing |
Acta Parasitol
December 2024
Biochemistry, Molecular Biology and Medicinal chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt.
Purpose: The aim of the present study is to assess the molluscicidal, larvicidal and genotoxicological activities of papain and how it can affect the host-parasite interactions.
Methods: Toxicity of papain on snails by making series of concentrations to calculate LC, and then study its larvicide effect on the free larval stages of S. mansoni and infection rate of snails.
Pestic Biochem Physiol
May 2024
Biochemistry, Molecular Biology and Medicinal chemistry Department, Theodor Bilharz Research Institute, Giza, Egypt; School of Biotechnology, Badr University in Cairo, Badr City, Cairo 11829, Egypt.
Biomphalaria spp. snails are freshwater gastropods that responsible for Schistosoma mansoni transmission. Schistosomiasis is a chronic illness that occurred in underdeveloped regions with poor sanitation.
View Article and Find Full Text PDFJ Helminthol
March 2024
Medical Parasitology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Schistosomiasis is a serious health issue in tropical regions, and natural compounds have gained popularity in medical science. This study investigated the potential effects of pumpkin seed oil (PSO) on snails (Ehrenberg, 1831), (Sambon, 1907) miracidium, and cercariae. The chemical composition of PSO was determined using gas chromatography/mass spectrometry.
View Article and Find Full Text PDFPlants (Basel)
August 2023
Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.
Diseases transmitted by mosquitoes and snails cause a large burden of disease in less developed countries, especially those with low-income levels. An approach to control vectors and intermediate hosts based on readily available essential oils, which are friendly to the environment and human health, may be an effective solution for disease control. Guava is a fruit tree grown on a large scale in many countries in the tropics, an area heavily affected by tropical diseases transmitted by mosquitoes and snails.
View Article and Find Full Text PDFPharmaceutics
April 2023
Chemistry Department, Faculty of Science, Menoufia University, Shibin El-Kom 32511, Egypt.
This work describes the synthesis of quinoline-based --heterocyclic arenes and their biological evaluation as molluscicides against adult snails as well as larvicides against larvae (miracidia and cercariae). Molecular docking studies were demonstrated to investigate their affinity for cysteine protease protein as an interesting target for antiparasitics. Compound showed the best docking results followed by in comparison to the co-crystallized ligand D1R reflected by their binding affinities and RMSD values.
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