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Intrinsically unidirectional chemically fuelled rotary molecular motors.
Nature
September 2022
Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Biological systems mainly utilize chemical energy to fuel autonomous molecular motors, enabling the system to be driven out of equilibrium. Taking inspiration from rotary motors such as the bacterial flagellar motor and adenosine triphosphate synthase, and building on the success of light-powered unidirectional rotary molecular motors, scientists have pursued the design of synthetic molecular motors solely driven by chemical energy. However, designing artificial rotary molecular motors operating autonomously using a chemical fuel and simultaneously featuring the intrinsic structural design elements to allow full 360° unidirectional rotary motion like adenosine triphosphate synthase remains challenging.
View Article and Find Full Text PDFRh-Catalyzed Aziridine Ring Expansions to Dehydropiperazines.
Org Lett
May 2020
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States.
Piperazines are prevalent in pharmaceuticals and natural products, but traditional methods do not typically introduce stereochemical complexity into the ring. To expand access to these scaffolds, we report Rh-catalyzed ring expansions of aziridines and sulfonyl-1,2,3-triazoles to furnish dehydropiperazines with excellent diastereocontrol. Productive ring expansion proceeds via a pseudo-1,4-sigmatropic rearrangement of an aziridinium ylide species.
View Article and Find Full Text PDFThe Manganese(I)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege.
Angew Chem Int Ed Engl
January 2020
Departement Chemie und Angewandte Biowissenschaften, Eidgenössische Technische Hochschule (ETH) Zürich, 8093, Zürich, Switzerland.
The bis(carbonyl) manganese(I) complex [Mn(CO) (1)]Br (2) with a chiral (NH) P macrocyclic ligand (1) catalyzes the asymmetric transfer hydrogenation of polar double bonds with 2-propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcohols in high yields (up to >99 %) and with excellent enantioselectivities (90-99 % ee). A stereochemical model based on attractive CH-π interactions is proposed.
View Article and Find Full Text PDFRetraction: A highly concise and practical route to clavaminols, sphinganine and (+)-spisulosine indium mediated allylation of α-hydrazino aldehyde and a theoretical insight into the stereochemical aspects of the reaction.
RSC Adv
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Physical Chemistry Division, CSIR-NCL (National Chemical Laboratory) Pune 411008 India.
[This retracts the article DOI: 10.1039/C3RA43048K.].
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