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Fluconazole Induces Cardiovascular Toxicity in Zebrafish by Promoting Oxidative Stress, Apoptosis, and Disruption of Key Developmental Genes.
Chem Biol Interact
January 2025
Department of Orthopedics, The Affiliated Wuxi Clinical College of Nantong University, Jiangsu, 214000, China. Electronic address:
This study systematically evaluated the toxic effects of fluconazole on the cardiovascular development of zebrafish. Zebrafish embryos were treated with different concentrations of fluconazole (200, 400, and 800 μg/ml) to observe its impact on heart development, reactive oxygen species (ROS) generation, apoptosis, and hemoglobin production. The results showed that as the concentration of fluconazole increased, significant changes in zebrafish heart structure were observed, along with a notable reduction in heart rate.
View Article and Find Full Text PDFHemoglobin in Submicron Particles (HbMPs) Is Stabilized Against Oxidation.
Antioxidants (Basel)
November 2024
Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Superoxide dismutase (SOD) and Catalase (CAT) play a crucial role as the first line of defense antioxidant enzymes in a living cell. These enzymes neutralize the superoxide anion from the autooxidation of oxyhemoglobin (Oxy-Hb) and convert hydrogen peroxides into water and molecular oxygen. In this study, we fabricated hemoglobin submicron particles (HbMPs) using the Coprecipitation Crosslinking Dissolution (CCD) technique and incorporating first-line antioxidant enzymes (CAT, SOD) and second-line antioxidant (ascorbic acid, Vit.
View Article and Find Full Text PDFFilgrastim Efficiency in Cats Naturally Infected with Feline Panleukopenia Virus.
Animals (Basel)
December 2024
Department of Public Health, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, Mihail Sadoveanu Alley, No. 8, 700489 Iasi, Romania.
Feline Panleukopenia (FPL) infection is caused by feline panleukopenia virus (FPV), and it is considered one of the most severe cat's infectious diseases. Since there is no specific antiviral treatment for FPL, the therapeutic protocol usually is focused on fluid therapy and supportive care. However, filgrastim, a granulocyte colony-stimulating factor (G-CSF) used in human medicine to treat neutropenia and leukopenia, has been lately used in treating FPV disease, providing promising results.
View Article and Find Full Text PDFGlycemic and weight control in people with type 2 diabetes: A real-world observational study in primary care.
Prim Care Diabetes
December 2024
Endocrinology and Nutrition Service, Santa Creu i Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain; Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Carlos III Health Institute (ISCIII), Barcelona, Spain; Spanish Diabetes Society, Former President, Spain.
Aims: To analyze glycemic and bodyweight control in people with type 2 diabetes mellitus (T2DM), and prescribing patterns in primary care.
Methods: We reviewed the electronic medical records of 5009 randomly selected T2DM patients, from 70 health centers in Spain. We analyzed results by age group and presence/absence of obesity.
Perioperative transfusion management in craniotomies: A national survey, a starting point for the evaluation of improvements in health care.
Rev Esp Anestesiol Reanim (Engl Ed)
December 2024
Departamento de Anestesiología y Reanimación, Hospital del Mar - Instituto de Investigación (IMIM), Barcelona, Spain.
Objective: To assess the perioperative management of haemostasis and transfusion practices in adult patients undergoing craniotomies.
Method: Online questionnaire addressed to Spanish anaesthesiologists and promoted by the Neurosciences and Haemostasis, Transfusion Medicine and Fluid Therapy Sections of SEDAR. The questionnaire was sent by email and social media, and was active between June and October 2022.
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