AI Article Synopsis
- The study examines how body mass (BM) and visceral fat (VA) affect glucose metabolism in morbidly obese women with the Pro12Pro genotype.
- It involved 25 women divided into two groups based on their body mass index (BMI), with assessments of glucose and insulin responses after a high-fat meal.
- Results showed that women with higher BM and VA had worse glucose metabolism, indicated by impaired fasting glucose, lower insulin sensitivity, and higher insulin resistance.
Article Abstract
Introduction: Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable.
Objective: To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro genotype.
Methods: Were selected 25 morbidly obese women. Groups were formed according to body mass index (BMI) [G1: 40-45 kg/m² (n = 17); G2: > 45 kg/m² (n = 8)]. Anthropometric, glycemia and insulinemia assessments (fasting, 60 and 120 minutes after high polyunsaturated fatty acids meal) were carried out. The insulin resistance (IR) and insulin sensitivity (IS) were assessed by HOMA-IR and QUICKI respectively.
Results: G2 had higher BMI and waist circumference, compared to G1, impaired fasting glucose, low IS and higher IR. The postprandial glucose was normal, but there was a higher insulin peak one hour after the meal in G2.
Conclusion: Increased BM and VA were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype.
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| http://dx.doi.org/10.3305/nh.2013.28.3.6372 | DOI Listing |
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