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Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer.
Oncogene
September 2024
Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Metabolic reprogramming and cellular senescence greatly contribute to cancer relapse and recurrence. In aging and treated prostate, persistent accumulating senescence-associated secretory phenotype (SASP) of cancer cells often limits the overall survival of patients. Novel strategic therapy with monoacylglycerol lipase (MGLL) upregulation that counters the cellular and docetaxel induced SASP might overcome this clinical challenge in prostate cancer (PCa).
View Article and Find Full Text PDFWounding the stroma: Docetaxel's role in dormant breast cancer escape.
PLoS Biol
September 2023
Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
The mechanistic underpinnings of breast cancer recurrence following periods of dormancy are largely undetermined. A new study in PLOS Biology reveals that docetaxel-induced injury of tumour stromal cells stimulates the release of cytokines that support dormancy escape of breast cancer cells.
View Article and Find Full Text PDFDocetaxel-Induced Interstitial Pneumonitis Detected on 68Ga-PSMA PET/CT.
Clin Nucl Med
May 2021
From the Departments of Nuclear Medicine and PET.
68Ga-PSMA PET/CT is a commonly performed procedure in the staging of intermediate- and high-risk prostate cancer after biochemical recurrence. Uptake of 68Ga-PSMA in benign conditions is also reported in the literature. Docetaxel is the mainstay of treatment in high-volume hormone-sensitive prostate cancer and castration-resistant prostate cancer.
View Article and Find Full Text PDFDocetaxel-induced fluid retention during adjuvant chemotherapy with S-1 plus docetaxel.
Clin J Gastroenterol
February 2021
Department of Gastroenterology, Ishikawa Prefectural Central Hospital, 2-1 Kuratukihigashi, Kanazawa, Ishikawa, 920-8530, Japan.
S-1 plus docetaxel is the standard postoperative adjuvant chemotherapy regimen for patients with stage III gastric cancer in Japan, which has increased the use of docetaxel. One of the most common adverse events of docetaxel, which is widely used to treat several malignancies, is fluid retention. Conversely, the most worrisome cause of ascites in patients who receive adjuvant chemotherapy is recurrence.
View Article and Find Full Text PDFNFIB promotes cell survival by directly suppressing p21 transcription in TP53-mutated triple-negative breast cancer.
J Pathol
February 2019
Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Canada.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited treatment options and poor prognosis. There is an urgent need to identify and understand the key factors and signalling pathways driving TNBC tumour progression, relapse, and treatment resistance. In this study, we report that gene copy numbers and expression levels of nuclear factor IB (NFIB), a recently identified oncogene in small cell lung cancer, are preferentially increased in TNBC compared to other breast cancer subtypes.
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