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The German Communities That Care Youth Survey: dimensionality and validity of risk factors.
Front Public Health
October 2024
Institute of Psychology, University of Hildesheim, Hildesheim, Germany.
Background: Communities That Care (CTC) is an evidence-based community change strategy for supporting healthy youth development. One of its key elements is the development of a community profile to identify and prioritise risk factors for health and behavioural problems in adolescents based on the CTC Youth Survey. The strategy was originally developed and evaluated in the United States.
View Article and Find Full Text PDFOral Cannabis Extract for Secondary Prevention of Chemotherapy-Induced Nausea and Vomiting: Final Results of a Randomized, Placebo-Controlled, Phase II/III Trial.
J Clin Oncol
December 2024
NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
Article Synopsis
- This clinical trial tested the effectiveness of an oral cannabis extract (THC:CBD) on adults experiencing severe nausea and vomiting from chemotherapy, despite using standard anti-nausea medications.
- The results showed that the cannabis extract significantly increased the rate of complete responses (no vomiting or need for rescue meds) from 8% to 24% compared to a placebo.
- While participants reported some mild side effects like sedation and dizziness, there were no serious adverse events linked to the cannabis treatment.
Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial.
Crit Care Resusc
June 2024
Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
Objective: This article describes the statistical analysis plan for the Biomarker-guided intervention to prevent AKI after major surgery (BigpAK-2) trial.
Design: Adaptive trial design with an interim analysis after enrolment of 618 evaluable patients.
Setting: The BigpAK.
Improving Surgical Care and Outcomes in Older Cancer Patients Through Implementation of a Presurgical Toolkit (OPTI-Surg)-Final Results of a Phase III Cluster Randomized Trial (Alliance A231601CD).
Ann Surg
October 2024
Department of Surgery, University of California, San Francisco, CA.
Objective: To assess the effect of a practice-level preoperative frailty screening and optimization toolkit (OPTI-Surg) on postoperative functional recovery and complications in elderly cancer patients undergoing major surgery.
Background: Frailty is common in older adults. It increases the risk of poor postoperative functional recovery and complications.
GammaGateR: semi-automated marker gating for single-cell multiplexed imaging.
Bioinformatics
June 2024
Department of Biostatistics, Vanderbilt University, 2525 West End Avenue, Suite 1100, Nashville, TN 37203-1741, United States.
Motivation: Multiplexed immunofluorescence (mIF) is an emerging assay for multichannel protein imaging that can decipher cell-level spatial features in tissues. However, existing automated cell phenotyping methods, such as clustering, face challenges in achieving consistency across experiments and often require subjective evaluation. As a result, mIF analyses often revert to marker gating based on manual thresholding of raw imaging data.
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