AI Article Synopsis
- Several bacterial pathogens have proteins with TIR domains that help them cause disease.
- A newly identified protein in Brucella, called BtpB, inhibits TLR signaling likely through MyD88, affecting immune responses.
- BtpB is important for Brucella's virulence and contributes to chronic brucellosis by interfering with host dendritic cell activation.
Article Abstract
Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703528 | PMC |
| http://dx.doi.org/10.3389/fcimb.2013.00028 | DOI Listing |
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