Patient: Female, 58 FINAL DIAGNOSIS: Listeria septicemia Symptoms: Nausea • vomitting • high fever • apathetic intelligence • repeated convulsion
Medication: Levofloxacin Clinical Procedure: - Specialty: Hematology Objective: Rare disease.
Background: Multiple myeloma is a hematological malignancy that frequently causes secondary diabetes due to chemotherapy using hormones and infection due to immunosuppression.
Case Reports: The patient was a 58-year-old woman with multiple myeloma and secondary diabetes complicated by listeria septicemia accompanied by central nervous system involvement. She initially received moxalactam and etimicin sulfate, but blood cultures detected Listeria monocytogenes. Levofloxacin was administered, but the symptoms did not improve. The patient ultimately died.
Conclusions: Listeria septicemia accompanied by central nervous system involvement in a patient with multiple myeloma and secondary diabetes is a relatively rare disease. Prevention, timely diagnosis, and treatment are the key steps for improvement. Blood glucose level control is another important factor that should be considered in the prevention and treatment for Listeria monocytogenes infection.
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http://dx.doi.org/10.12659/AJCR.889168 | DOI Listing |
iScience
December 2024
The Affiliated Zhongda Hospital, Clinical Medical College, Southeast University, Nanjing, Jiangsu, China.
Sepsis, a leading cause of mortality in intensive care units worldwide, lacks effective treatments for advanced-stage sepsis. Therefore, understanding the underlying mechanisms of this disease is crucial. This study reveals that invariant natural killer T (iNKT) cells have an opposing role in the progression of sepsis by suppressing regulatory T (Treg) cell differentiation and function.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
December 2024
Department of Geriatric Respiratory Medicine, Hebei General Hospital, Shijiazhuang050000, China.
Microorganisms
October 2024
Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Trieda SNP 1, 040 11 Košice, Slovakia.
is a Gram-positive bacterium that causes listeriosis, a severe foodborne illness that is particularly dangerous during pregnancy. It thrives in diverse environments, including refrigerated conditions and food production facilities, due to its adaptability to varying temperatures, pH levels, and salt concentrations. Its virulence stems from the ability to invade host cells, particularly macrophages and epithelial cells, and avoid, or at least postpone, immune detection by utilizing virulence factors such as internalins, listeriolysin O, and actin assembly-inducing protein.
View Article and Find Full Text PDFMicroorganisms
October 2024
Animal Disease Diagnostics Laboratory, Regional Department Križevci, Croatian Veterinary Institute, 48260 Križevci, Croatia.
Listeriosis is a dangerous zoonosis caused by bacteria of the genus , with (LM) being the most pathogenic species. has been detected in various animal species and in humans, and its ability to evolve from an environmental saprophyte to a powerful intracellular pathogen is driven by the invasion mechanisms and virulence factors that enable cell invasion, replication and cell-to-cell spread. Key regulatory systems, including positive regulatory factor A (PrfA) and the stress-responsive sigma factor σ, control the expression of virulence genes and facilitate invasion of host cells.
View Article and Find Full Text PDFJ Clin Med
October 2024
Twin Pregnancy Unit, Gynecology and Obstetrics 2U, A.O.U. Città della Salute e della Scienza, Sant'Anna Hospital, University of Turin, 10126 Turin, Italy.
Listeriosis is a rare but severe foodborne disease caused by (LM), a small facultative intracellular bacillus. When occurring in pregnant women, it can be vertically transmitted to the fetus and the newborn. Infected women usually display aspecific and mild symptoms, and rarely develop the severe forms of the disease (such as neurolisteriosis).
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