Two experiments examined whether the processing of the magnitude of fractions is global or componential. Previously, some authors concluded that adults process the numerators and denominators of fractions separately and do not access the global magnitude of fractions. Conversely, others reported evidence suggesting that the global magnitude of fractions is accessed. We hypothesized that in a fraction matching task, participants automatically extract the magnitude of the components but that the activation of the global magnitude of the whole fraction is only optional or strategic. Participants carried out same/different judgment tasks. Two different tasks were used: a physical matching task and a numerical matching task. Pairs of fractions were presented either simultaneously or sequentially. Results showed that participants only accessed the representation of the global magnitude of fractions in the numerical matching task. The mode of stimulus presentation did not affect the processing of fractions. The present study allows a deeper understanding of the conditions in which the magnitude of fractions is mentally represented by using matching tasks and two different modes of presentation.
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http://dx.doi.org/10.3389/fpsyg.2013.00385 | DOI Listing |
Cancer Sci
March 2025
Department of Chemical Biology and Therapeutics, SJCRH, Memphis, Tennessee, USA.
Although primary tumor control rates after surgery and/or radiation therapy (RT) are generally high in patients with Ewing sarcoma (EWS), those with unresectable tumors have failure rates approaching 30% and experience poorer outcomes. Additionally, although metastatic site irradiation is associated with improved survival, dose, and volume effects influence the long-term toxicity risk. Consequently, it is important to identify novel systemic agents to enhance the therapeutic ratio of RT.
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March 2025
Department of Materials Science and Engineering, Materials Research Laboratory, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Helical-helical polypeptide polymerized ionic liquid block copolymers (PPIL BCPs) are synthesized to investigate the role of helical structure on self-assembly and ionic conductivity. PPIL BCPs, consisting of a cationic polypeptide (PTPLG) with bis(trifluoromethane sulfonimide) (TFSI) counterion and varying lengths connected to a length-fixed neutral poly-(γ-benzyl--glutamate) (PBLG) block, exhibit stable helical conformations with minimal glass transition (T) variation. Here, we show that increasing PIL composition leads to a transition from poorly ordered to highly ordered lamellar (LAM) structures with the highest PIL content BCP forming a bilayer LAM structure with close-packed helices.
View Article and Find Full Text PDFSci Rep
March 2025
Toronto General Hospital Research Institute, University Health Network, Toronto, M5G 2C4, Canada.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i), such as empagliflozin, have shown remarkable benefits in reducing cardiovascular events and mortality in patients with heart failure irrespective of diabetes. Because of the magnitude of the benefits and broad application in both heart failure with reduced and preserved ejection fraction, there have been concerted efforts to identify a mechanism for the observed benefits. One hypothesis is that SGLT2i act directly on the heart.
View Article and Find Full Text PDFSci Rep
March 2025
Institute of Anatomy, University of Bern, Bern, Switzerland.
Microbeam Radiation Therapy is a preclinical form of spatially fractionated radiation therapy that utilizes synchrotron X-rays to deliver highly heterogeneous dose distributions at a micrometric scale. This radiation scheme has been shown to facilitate the induction of controlled and reversible vascular permeability, enhancing treatment efficacy of systemic therapeutic agents. Despite the promising preclinical results, translating microbeam SFRT to the clinic has been hindered by a reliance on synchrotron sources that operate at dose rates orders of magnitude greater than what is possible with clinical machines.
View Article and Find Full Text PDFAm J Cardiovasc Drugs
March 2025
2nd Department of Nephrology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, St. Kyriakidi 1, 54636, Thessaloniki, Greece.
Finerenone is a novel nonsteroidal mineralocorticoid receptor (MR) antagonist (MRA) with unique pharmacological properties that offer potent and selective blockade of the MR with a more favorable side effect profile than spironolactone and eplerenone. In a large phase III clinical trial involving 13,026 patients with type 2 diabetes mellitus and a broad spectrum of chronic kidney disease, finerenone provoked a substantial placebo-subtracted reduction in the risk of hospitalization for heart failure (HF). These preliminary clinical trial data, along with the ongoing uncertainty about the safety and efficacy of MR antagonism in patients with HF and higher levels of ejection fraction have provided the rationale for the design of the FINEARTS-HF (Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients with Heart Failure) trial.
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