Detection of single-nucleotide variations by monitoring the blinking of fluorescence induced by charge transfer in DNA.

Chembiochem

The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Japan.

Published: August 2013

Charge transfer dynamics in DNA: Photo-induced charge separation and charge-recombination dynamics in DNA was assessed by monitoring the blinking of fluorescence. Single nucleotide variations, mismatch and one base deletion, were differentiated based on the length of the off-time of the blinking, which corresponds to the lifetime of the charge-separated state.

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http://dx.doi.org/10.1002/cbic.201300380DOI Listing

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