AI Article Synopsis
- The study investigates the role of oxidative stress and autoimmunity in boys with undescended testes (UDT) and how they relate to sub-fertility and testicular cancer.
- Increased levels of malondialdehyde (MDA), a marker for oxidative stress, were found in boys with UDT compared to healthy controls, indicating oxidative damage.
- The study also shows that higher levels of CA II autoantibodies in UDT boys suggest an autoimmune response may be connected to oxidative stress.
Article Abstract
Purpose: In the pathogenesis of sub-fertility/infertility and testicular cancer related to undescended testes, oxidative stress, inflammation and autoimmunity are important factors. Therefore, the present study was designed to determine serum oxidative stress markers and carbonic anhydrase (CA) II autoantibodies in boys with undescended testes (UDT), and to investigate the relationship between these parameters.
Methods: Serum CA II autoantibody titers, malondialdehyde (MDA), ischemia modified albumin (IMA), protein carbonyl content and soluble CD40 ligand (sCD40L) levels were measured in 59 boys with UDT and 30 healthy subjects.
Results: MDA levels were significantly higher in the UDT group compared with the control group (p = 0.003). There was no significant difference between serum IMA, sCD40L or protein carbonyl levels. CA II autoantibody titers in the UDT group were significantly higher compared with those of the control group (p = 0.048). A weak positive correlation was determined between anti-CA II antibody titers and MDA and IMA levels (p = 0.041, p = 0.005, respectively).
Conclusions: MDA is the most reliable and decisive biochemical marker displaying oxidative damage in undescended testes, and an autoimmune response may be triggered by oxidative stress against CA II during the UDT process.
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| http://dx.doi.org/10.1007/s00345-013-1129-9 | DOI Listing |
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