AI Article Synopsis
- This study investigates the relationship between the angiotensinogen (AGT) gene variant M235T and cancer risk through a meta-analysis of existing research.
- It includes data from seven articles with a total of nearly 4,000 cancer cases and over 6,600 controls, finding a slight association between the AGT M235T variant and cancer risk, but this result was not consistent upon further analysis.
- Ultimately, the analysis concludes that there is no significant association between the AGT M235T variant and cancer risk, emphasizing the need for larger, well-designed studies to further evaluate this question.
Article Abstract
Objective: The angiotensinogen (AGT) gene has been considered to be implicated in the development of cancer. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of AGT M235T variant with cancer risk.
Methods: Published literature from PubMed and Embase were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using a fixed- or random-effects model.
Results: A total of seven articles including eight studies (3639 cancer cases and 6684 controls) for AGT M235T variant were included. The present meta-analysis showed that AGT M235T variant was marginally associated with cancer risk under dominant model (OR=1.12, 95% CI=1.02-1.24). However, the positive association was not stable after sensitivity analysis. Further subgroup analysis by cancer type did not suggest any association of AGT M235T variant with various cancers (all p>0.05).
Conclusion: The present meta-analysis demonstrated that AGT M235T variant was not associated with risk of all cancer or various cancers. Further well-designed studies with large sample size should be conducted to confirm or refute the non-significant association.
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| http://dx.doi.org/10.1177/1470320313496859 | DOI Listing |
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