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A robust multimodal brain MRI-based diagnostic model for migraine: validation across different migraine phases and longitudinal follow-up data.
J Headache Pain
January 2025
Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea.
Inter-individual variability in symptoms and the dynamic nature of brain pathophysiology present significant challenges in constructing a robust diagnostic model for migraine. In this study, we aimed to integrate different types of magnetic resonance imaging (MRI), providing structural and functional information, and develop a robust machine learning model that classifies migraine patients from healthy controls by testing multiple combinations of hyperparameters to ensure stability across different migraine phases and longitudinally repeated data. Specifically, we constructed a diagnostic model to classify patients with episodic migraine from healthy controls, and validated its performance across ictal and interictal phases, as well as in a longitudinal setting.
View Article and Find Full Text PDFAsymmetric dynamics of GABAergic system and paradoxical responses of GABAergic neurons in piriform seizures.
Epilepsia
December 2024
Shanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science and Institutes of Brain Science, Fudan University, Shanghai, China.
Objective: The piriform cortex (PC) plays a critical role in ictogenesis, where an excitation/inhibition imbalance contributes to epilepsy etiology. However, the epileptic dynamics of the gamma-aminobutyric acid (GABA) system and the precise role of GABAergic neurons within the PC in epilepsy remain unclear.
Methods: We combined Ca and GABA sensors to investigate the dynamics of Gad2-expressing neurons and GABA levels, and selectively manipulated GABAergic neurons in the PC through chemogenetic inhibition and caspase3-mediated apoptosis targeting Gad2 interneurons.
Anatomical categorization of insulo-opercular focal cortical dysplasia and the spatial patterns of stereoelectroencephalography.
Epilepsia
December 2024
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Objective: This study was undertaken to anatomically categorize insulo-opercular focal cortical dysplasia (FCD) lesions according to their location and extent, and to summarize corresponding stereoelectroencephalographic (SEEG) patterns to guide preoperative evaluation and surgical planning.
Methods: Patients who underwent epilepsy surgery for insulo-opercular FCD between 2015 and 2022 were enrolled. FCD lesions were categorized into insular, peri-insular, opercular, and complex types based on their location and extent, as ascertained from electroclinical and neuroimaging data.
Threshold-dependent association between non-rapid eye movement obstructive sleep apnea and interictal epileptiform discharges: A hospital study.
J Sleep Res
October 2024
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Obstructive sleep apnea frequently coexists with epilepsy, potentially influencing its pathophysiology. However, the effect of obstructive sleep apnea severity on interictal epileptiform discharges is not well understood. To explore this, we studied 108 Asian patients with epilepsy who underwent single-night polysomnography.
View Article and Find Full Text PDFPreserved working memory performance along with subcortical modulation during peri-ictal phases in spontaneous migraine attacks.
Headache
October 2024
ISR-Lisboa/LARSyS, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Objective: To analyze cognitive performance and brain activation during a working memory task in patients with migraine during various phases of the migraine cycle and compare to healthy participants.
Background: Cognitive difficulties reported during migraine attacks remain poorly understood, despite evidence that the lateral frontoparietal network undergoes reversible disturbances and decreased activation during attacks. Recent findings in resting state functional magnetic resonance imaging suggest that brain areas involved in this network interact with subcortical regions during spontaneous migraine attacks.
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