Five new dibenzocyclooctane lignans, schisanwilsonins K-O, together with eighteen known lignans were isolated from the stems of Schisandra wilsoniana. The structures of these new compounds were elucidated by spectroscopic methods, including 2D-NMR techniques. Several compounds were found to show anti-HIV and anti-HBV activity.
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Cardioprotective Potential of Berries of Turcz. (Baill.), Their Components and Food Products.
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Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/3, 90-236 Lodz, Poland.
() berries, originally a component of traditional herbal medicine in China, Korea, and other east Asian countries, are also valuable agents in modern phototherapy. berry preparations, including extracts and their chemical components, demonstrate anti-cancer, hepatoprotective, anti-inflammatory, and antioxidant properties, among others. These valuable properties, and their therapeutic potential, are conditioned by the unique chemical composition of berries, particularly their lignan content.
View Article and Find Full Text PDFSchisanwilsonins H and I, two new dibenzocyclooctane lignans from the fruits of .
J Asian Nat Prod Res
January 2023
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Two new dibenzocyclooctane lignans, schisanwilsonins H () and I (), together with eight known compounds gomisin J (), wulignan A (), gomisin S (), tigloylgomisin P (), gomisin O (), (-)-gomisin K (), rubschisantherin () and wuweizisu C () were isolated from the 95% ethanol extract of the fruits of . exhibited anti-HBV activity with potency against HBsAg and HBeAg secretion by 37.1% and 32.
View Article and Find Full Text PDFNew Thymoquinol Glycosides and Neuroprotective Dibenzocyclooctane Lignans from the Rattan Stems of Schisandra chinensis.
Chem Biodivers
September 2016
Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, 24 HePing Road, Harbin, 150040, P. R. China.
Three new lignans (1 - 3), together with four new thymoquinol glycosides (4 - 7), were isolated from 70%-EtOH extract of the rattan stems of Schisandra chinensis. The structures of 1 - 7 were elucidated by detailed spectroscopic analyses, and these new compounds were identified as pinobatol-9-O-β-d-glucopyranoside (1), 1,2,13,14-tetramethoxydibenzocyclooctadiene 3,12-O-β-d-diglucopyranoside (2), 3,7-dihydroxy-1,2,13,14-tetramethoxydibenzocyclooctadiene 12-O-β-d-glucopyranoside (3), thymoquinol 2-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (4), thymoquinol 2-O-α-d-arabinofuranosyl-(1→6)-β-d-glucopyranoside (5), thymoquinol 5-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (6), and thymoquinol 5-O-α-d-arabinofuranosyl-(1→6)-β-d-glucopyranoside (7). The neuroprotective activity of 1 - 7 was evaluated on PC12 cells with neurotoxicity induced by amyloid-beta 1 - 42 (Aβ ).
View Article and Find Full Text PDFDibenzocyclooctane lignans from the stems of Schisandra wilsoniana.
Planta Med
August 2013
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China.
Five new dibenzocyclooctane lignans, schisanwilsonins K-O, together with eighteen known lignans were isolated from the stems of Schisandra wilsoniana. The structures of these new compounds were elucidated by spectroscopic methods, including 2D-NMR techniques. Several compounds were found to show anti-HIV and anti-HBV activity.
View Article and Find Full Text PDFQuantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS.
Phytochem Anal
August 2012
Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.
Introduction: Direct analysis in real time (DART) ion source is a powerful ionising technique for the quick and easy detection of various organic molecules without any sample preparation steps, but the lack of quantitation capacity limits its extensive use in the field of phytochemical analysis.
Objective: To improvise a new system which utilize DART-MS as a hyphenated detector for quantitation.
Methodology: A total extract of Schisandra chinensis fruit was analyzed on a TLC plate and three major lignan compounds were quantitated by three different methods of UV densitometry, TLC-DART-MS and HPLC-UV to compare the efficiency of each method.
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