Since 2000 several bluetongue virus (BTV) incursions have occurred in Sardinia (Italy) involving serotypes 1, 2, 4, 8 and 16. In October 2012, new BT outbreaks caused by BTV-1 and BTV-4 were reported. Nearly 500 flocks were infected and 9238 sheep died because of the infection. When sequenced, Seg-10 of both strains shared 99% similarity at nucleotide level with BTV strains that have circulated in the Mediterranean basin in the last few years. Similarly, Seg-5 sequences of BTV-1 and BTV-4 newly isolated Sardinian strains are identical and cluster together with recent BTV-1 circulating in the Mediterranean Basin and the BTV-4 strains isolated in Tunisia in 2007 and 2009. These BTV-4 strains differ from the ones that circulated in Europe from 2003 to 2005 and appear to be reassortant strains.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.meegid.2013.06.028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
HEMATOLOGY AND BIOCHEMICAL REFERENCE INTERVALS AND SEROPREVALENCE OF HEMORRHAGIC DISEASES FOR FREE-RANGING MULE DEER () IN WEST TEXAS.
J Zoo Wildl Med
December 2024
Texas Parks and Wildlife Department, Austin, Texas, 78744 USA.
Wildlife species are routinely captured for translocation, general health monitoring, and research-based pursuits to guide wildlife management. Mule deer () were captured for various research projects and management actions in the Trans-Pecos and Panhandle regions of Texas from 2015 to 2019. The objective of this study was to develop hematologic and biochemical parameters for free-ranging mule deer in Texas and to develop a health monitoring system for current and future mule deer population management.
View Article and Find Full Text PDFBackground: Bluetongue virus serotype 3 (BTV-3) was detected for the first time in cattle and sheep in southern England in 2023, the first UK BTV incursion for more than 15 years. Clinical signs were not observed, yet severe clinical disease and mortality were reported during recent BTV-3 outbreaks in northern Europe.
Methods: To investigate the clinical disease and infection kinetics associated with this UK BTV-3 strain, five British sheep were infected with a UK BTV-3 isolate using Culicoides biting midges.
A comparative exploration of mRNA capping enzymes.
Biotechnol Notes
November 2024
Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China.
With the wide application of messenger RNA (mRNA) technology in medicine and vaccine fields, higher requirements are put forward for mRNA expression efficiency . Since the 5' cap structure can spatially protect mRNA from exonuclease degradation and enhance the initiation of translation reactions, mRNA caps are a promising option to improve the efficiency of mRNA expression . In order to obtain more efficient mRNA capping enzymes, seven mRNA capping enzymes from different viral sources were explored in this study.
View Article and Find Full Text PDFIn Silico Development of a Multi-Epitope Subunit Vaccine against Bluetongue Virus in Using Immunoinformatics.
Pathogens
October 2024
ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru 560064, India.
The bluetongue virus (BTV), transmitted by biting midges, poses a significant threat to livestock globally. This orbivirus induces bluetongue disease, leading to substantial economic losses in the agricultural sector. The current control measures have limitations, necessitating the development of novel, efficient vaccines.
View Article and Find Full Text PDFIdentification of NECTIN1 as a novel restriction factor for flavivirus infection.
mBio
December 2024
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Article Synopsis
- NECTIN1 is a cell adhesion molecule known mainly for its interaction with herpesviruses, but this study reveals its new role as a barrier against flavivirus infections, specifically BVDV.
- The researchers found that reducing NECTIN1 levels increased BVDV infections and identified NECTIN1's IgV domain as crucial for its inhibiting function, affecting how BVDV attaches to cells.
- The study also showed NECTIN1’s broader antiviral activity against several other viruses, highlighting its potential significance as a restriction factor in controlling flavivirus infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!