AI Article Synopsis
- The study examined the impact of aminoguanidine on the liver of diabetic rats that underwent physical exercise, utilizing histological methods.
- It involved five groups of rats: a control group, a sedentary diabetic group, a trained diabetic group, and two groups treated with aminoguanidine either sedentary or trained.
- Findings indicated that while aminoguanidine did not affect liver tissue, exercise training resulted in significant positive changes in liver cells, suggesting that moderate exercise can mitigate diabetes-related liver damage without insulin use.
Article Abstract
Background: This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.
Methods: THE RATS USED IN THIS STUDY WERE DIVIDED INTO FIVE GROUPS: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.
Results: The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.
Conclusion: Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7983740 | PMC |
| http://dx.doi.org/10.1186/2251-6581-12-40 | DOI Listing |
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