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Bacterial contamination of mobile handwashing stations in hospital settings in the Democratic Republic of the Congo.
Antimicrob Resist Infect Control
December 2024
Department of Microbiology, Immunology and Transplantation, KU Leuven, Louvain, Belgium.
Background: As part of the containment of the COVID-19 pandemic, mobile handwashing stations (mHWS) were deployed in healthcare facilities in low-resource settings. We assessed mHWS in hospitals in the Democratic Republic of the Congo for contamination with Gram-negative bacteria.
Methods: Water and soap samples of in-use mHWS in hospitals in Kinshasa and Lubumbashi were quantitatively cultured for Gram-negative bacteria which were tested for antibiotic susceptibility.
Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women.
Cochrane Database Syst Rev
December 2024
Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago, Wellington, New Zealand.
Background: Pelvic floor muscle training (PFMT) is a recommended treatment for female stress, urgency, and mixed urinary incontinence. Training varies in exercise type (pelvic floor muscles contracting with and without other muscles), dose, and delivery (e.g.
View Article and Find Full Text PDFReassessing mirtazapine and akathisia: A case report on its efficacy in treating severe, treatment-resistant akathisia and a review of the evidence.
SAGE Open Med Case Rep
November 2024
Department of Psychiatry, London Health Sciences Centre, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Article Synopsis
- * A 44-year-old man experienced severe, treatment-resistant akathisia from haloperidol, and standard treatments like benzodiazepines and benztropine were ineffective, leaving him in considerable distress.
- * Introducing mirtazapine at a low dose successfully improved his symptoms, as shown by a significant drop in the Barnes Akathisia Rating Scale score, showcasing mirtazapine's potential as an effective treatment for resistant cases of akathisia.
Ketamine for the Treatment of Psychiatric Disorders: A Systematic Review and Meta-Analysis.
CNS Spectr
November 2024
Brain and Cognition Discovery Foundation, Toronto, ONM5S 1M2, Canada.
Background: Inadequate response to first- and second-line pharmacological treatments for psychiatric disorders is commonly observed. Ketamine has demonstrated efficacy in treating adults with treatment-resistant depression (TRD), with additional off-label benefits reported for various psychiatric disorders. Herein, we performed a systematic review and meta-analysis to examine the therapeutic applications of ketamine across multiple mental disorders, excluding mood disorders.
View Article and Find Full Text PDFUnveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids.
Acta Pharm
November 2024
1University of Zagreb, Faculty of Pharmacy and Biochemistry, 10 000 Zagreb, Croatia.
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated their antiglioblastoma potential and mechanism of action (inhibition of DYRK1A, Hsp90, anti-oxidative activity). The results have shown that triazole-type harmicens, namely , with a ferrocene moiety in C-3 position of the β-carboline ring ( = 3.
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