AI Article Synopsis
- Multifocal papillary thyroid carcinoma (mPTC) accounts for 20-30% of all cases of papillary thyroid carcinoma (PTC) and can have multiple tumor types.
- A case study is presented involving a 44-year-old woman with mPTC, featuring one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs.
- This case reveals the simultaneous presence of two distinct BRAF mutations (V600E and K601E) in the different tumor types, highlighting unique genetic characteristics.
Article Abstract
Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701828 | PMC |
| http://dx.doi.org/10.4132/KoreanJPathol.2013.47.3.293 | DOI Listing |
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