Each subunit of voltage-gated cation channels comprises a voltage-sensing domain and a pore region. In a paper recently published in Cell Research, Li et al. showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760620 | PMC |
| http://dx.doi.org/10.1038/cr.2013.89 | DOI Listing |
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