Multimarker approach for identifying and documenting mitigation of cardiovascular risk.

Future Cardiol

Cleveland Heart Lab, 6701 Carnegie Avenue, Cleveland, OH 44106, USA.

Published: July 2013

AI Article Synopsis

  • The use of lipids to assess cardiovascular risk has been effective, leading to a notable decrease in serious heart attacks.
  • Research is shifting towards nonlipid inflammatory biomarkers since many patients with normal lipid levels still experience heart issues.
  • A study of over 95,000 patients highlights the benefits of a multimarker approach in evaluating risk and discusses the potential future advancements in this area.

Article Abstract

The widespread use of lipids to define risk has been a success based on the dramatic decrease in the incidence of transmural myocardial infarctions. This success and the fact that many patients with normal lipid levels go on to have acute coronary syndrome have led to investigations on the use of nonlipid-based inflammatory biomarkers to predict risk. Interestingly, as the physiology reflected by distinct biomarkers is better understood, there is increasing interest in multimarker approaches to determine risk and where a given patient may be on a spectrum of risk. In this perspective, we review data from over 95,000 patients who had a multimarker annual wellness panel to demonstrate the utility of multiple markers in defining those patients at risk. We discuss a novel multimarker panel for cardiovascular risk, define the differences between a multimarker approach and expensive amalgamations of multiple markers, and discuss how the field may develop in the future.

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Source
http://dx.doi.org/10.2217/fca.13.27DOI Listing

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