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Immune Thrombocytopenic Purpura Secondary to Cytomegalovirus (CMV) Infection: A Clinical Case.
Cureus
December 2024
General and Family Medicine, Câmara de Lobos Health Center, Serviço de Saúde da Região Autónoma da Madeira, Entidade Pública Empresarial da Região Autónoma da Madeira (SESARAM, EPERAM), Câmara de Lobos, PRT.
Immune thrombocytopenic purpura (ITP) is an autoimmune condition characterized by a reduced platelet count due to enhanced peripheral destruction and impaired platelet production. While thrombocytopenia is a well-documented complication of various viral infections, cytomegalovirus (CMV), a member of the Herpesviridae family, is primarily associated with infections in immunocompromised patients and is rarely implicated in causing severe thrombocytopenia in immunocompetent patients. This article aims to highlight the importance of considering CMV as a significant etiological factor in ITP, particularly in cases of asymptomatic thrombocytopenia.
View Article and Find Full Text PDFMalignant thyroid neoplasm with ectopic Cushing's syndrome.
BMJ Case Rep
December 2024
Endocrinology, PGIMER, Chandigarh, India.
An adult man in his 30s with newly diagnosed diabetes mellitus and hypertension presented with a 33 lb weight gain, generalised swelling and classic Cushingoid features, including proximal muscle weakness, easy bruisability, wide violaceous striae and a painless, progressively enlarging right-sided neck swelling over the past month. Physical examination revealed a 4×4 cm thyroid mass, facial plethora and dorsocervical fat pads. Laboratory investigations confirmed hypercortisolism with elevated cortisol and Adrenocorticotropic Hormone(ACTH), with non-suppression on dexamethasone suppression tests.
View Article and Find Full Text PDF[Clinical, demographic and histopathological characteristics of individuals with Kaposi's sarcoma and living with HIV in Mexico].
Rev Med Inst Mex Seguro Soc
November 2024
Secretaría de Salud, Hospital General de México "Dr. Eduardo Liceaga", Servicio de Dermatología Dr. Mario Magaña Lozano. Ciudad de México, México.
Article Synopsis
- KS is the most common cancer among HIV-positive individuals in developing countries, significantly impacting their quality of life.
- The study included 28 male HIV-positive patients diagnosed with KS, revealing that most had low CD4+ counts, high viral loads, and common skin lesions associated with the disease.
- Antiretroviral therapy demonstrated a long-term protective effect against KS, but opportunistic infections, particularly tuberculosis, were prevalent, emphasizing the need for a comprehensive approach in managing both KS and related infections.
Detailed primary localised cutaneous nodular amyloidosis clinical and pathological workup.
BMJ Case Rep
November 2024
Hematology and Oncology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA.
Primary localised cutaneous nodular amyloidosis is a rare form of amyloidosis characterised by amyloid deposition in the skin but a lack of further organ involvement; therefore, it is not a systemic disease that progresses to complication. Limited knowledge exists on the causes and outcomes of long-term cutaneous nodular amyloidosis patients. This study reports a case of a woman in her late 80s presenting with a primary cutaneous nodular amyloidosis, with yellow, white plaques and a focal area of violaceous nodules along the inferior lumbar spine.
View Article and Find Full Text PDFProgression of Sclerouveitis to Endogenous Endophthalmitis.
Case Rep Ophthalmol Med
August 2024
Department of Ophthalmology Jones Eye Institute University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas, USA.
We describe a unique case of sclerouveitis that progressed to endogenous endophthalmitis in a 69-year-old male with chronic lymphocytic leukemia (CLL). We highlight the risk of treating sclerouveitis with oral corticosteroids, which can exacerbate an infection and contribute to disease progression. A 69-year-old male with CLL on zanubrutinib, a second-generation Bruton's tyrosine kinase inhibitor, was admitted to the hospital for osteomyelitis of the left foot.
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