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Radical scavenging capacity of 2,4-dihydroxy-9-phenyl-1H-phenalen-1-one: a functional group exclusion approach. | LitMetric

Radical scavenging capacity of 2,4-dihydroxy-9-phenyl-1H-phenalen-1-one: a functional group exclusion approach.

Org Lett

Instituto de Química, Síntesis y Biosíntesis de Metabolitos Naturales, Universidad de Antioquia, A.A 1226, Medellín, Colombia.

Published: July 2013

AI Article Synopsis

Article Abstract

2,4-Dihydroxy-9-phenyl-1H-phenalen-1-one (4-hydroxyanigorufone, 1), a compound isolated from Anigozanthos flavidus and Monochoria elata, displayed a high radical scavenging capacity in the ORAC assay. A systematic approach was adopted in order to explore the effect of each functional group. H-Atom transfer from the phenolic hydroxyl, a captodative effect from the hydroxy ketone, and the presumed involvement of the phenyl ring in the termination step of the radical reaction were disclosed as relevant features of this type of antioxidant.

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Source
http://dx.doi.org/10.1021/ol400384zDOI Listing

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