To carry out normovolemic haemodilution in the best security conditions we elaborate a new method of preoperative haemodilution. Collection of red cell concentrates and adequate compensation are made either in the blood bank or at the patient's bed side. There are two ways of proceeding: *manual plasmapheresis technic is used for the collection of less than 450 ml packed red cells; *collection of more than 450 ml packed red cells is carried out on a PCS Haemonetics cell separator. CPD autologous red cells concentrates prepared in that way can be stored to meet the patient's need during and after the operation. The patient is identified as donor and receiver as regards laboratory analysis and computer treatment as well. Information's transmission between blood bank hospital and clinics is secured with the same document. This method enables homologues transfusion save and completes autologous transfusion in 68% cases among 106 patients. It is to be noticed that none of the 98 haemodiluted patients suffered from thrombosis.

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