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Article Abstract
We report that Cas9/gRNA mediates efficient genetic modifications in Drosophila. Through targeting seven loci, we achieved a germline efficiency of up to 100%. Genes in both heterochromatin and euchromatin can be modified efficiently. Thus the Cas9/gRNA system is an attractive tool for rapid disruption of essentially any gene in Drosophila.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761309 | PMC |
| http://dx.doi.org/10.1534/genetics.113.153825 | DOI Listing |
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