AI Article Synopsis
- The study compared neuropsychological and psychiatric outcomes in patients with poorly controlled idiopathic generalized epilepsy (IGE) and those with medically refractory temporal lobe epilepsy (TLE).
- Patients with IGE demonstrated longer completion times on cognitive tests and lower performance IQ than those with TLE, despite experiencing more seizures.
- Interestingly, IGE patients reported lower depression scores, which were inversely correlated with the duration of their epilepsy, suggesting different underlying neurological processes between the two conditions.
Article Abstract
The neuropsychological and psychiatric outcomes of patients with poorly controlled idiopathic generalized epilepsy (IGE) have not been well characterized. The current study aimed to compare these outcomes to a group of patients with medically refractory temporal lobe epilepsy (TLE). A retrospective review of patients admitted to the epilepsy monitoring unit identified 19 patients with IGE and 23 patients with TLE who underwent neuropsychological and psychiatric evaluations. Patients with IGE required a longer time to complete the Trail Making Tests and had lower performance IQ compared to patients with TLE. Despite a higher burden of convulsions, patients with IGE had lower depression scores on the Beck Depression Inventory-II (BDI-II) than patients with TLE. In the group with IGE, the BDI-II scores were inversely correlated with epilepsy duration. These findings indicate that patients with IGE have lower performance IQ, impaired performance on tests of executive functioning, and lower depression scores compared to patients with TLE, implicating different pathophysiological processes.
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| http://dx.doi.org/10.1016/j.yebeh.2013.05.020 | DOI Listing |
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