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A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells. | LitMetric

We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug is able to monitor drug delivery and cellular imaging.

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Source
http://dx.doi.org/10.1039/c3cc42653jDOI Listing

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