AI Article Synopsis
- Accumulation of amyloidogenic Aβ peptides in the brain is linked to Alzheimer disease, but their effects on platelets need clarification.
- Immobile Aβ peptides promote platelet adhesion and spreading via specific metalloproteinase-sensitive receptors.
- These peptides enhance platelet activation and signaling, suggesting a role in thrombus formation related to Alzheimer's disease.
Article Abstract
Accumulation of amyloidogenic Aβ peptides in the brain contributes to the onset of Alzheimer disease. Aβ peptide deposits are also present in blood vessel walls, mainly deriving from circulating platelets. However, their effect on platelet function is unclear. We demonstrate that immobilized Aβ peptides induce platelet adhesion and spreading through metalloproteinase-sensitive surface receptors. Aβ peptides also fasten platelet spreading on collagen, and support the time- and ADP-dependent activation of adherent platelets, leading to stimulation of several signalling proteins. Our results indicate a potential role for peripheral Aβ peptides in promoting platelet adhesion and activation in the initiation of thrombus formation.
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| http://dx.doi.org/10.1016/j.febslet.2013.06.041 | DOI Listing |
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