AI Article Synopsis
- The article examines the phenomenon of refractoriness in exercise-induced bronchoconstriction, where repeated exercise leads to reduced airway responsiveness.
- Researchers highlight that the exact mechanism behind this protective response is still unclear.
- The authors suggest that the desensitization of a specific receptor (G protein-coupled cysteinyl leukotriene receptor1) could be the cause, influenced by the interaction between leukotrienes and prostaglandins.
Article Abstract
This article discusses the available literature on refractoriness in exercise-induced bronchoconstriction, namely, a decrease in airway responsiveness with repeated exercise challenges. The mechanisms of this naturally occurring protective feature is unknown. Reviewing previous studies together with findings in more recent studies, the authors propose desensitization of the G protein-coupled cysteinyl leukotriene receptor1 as the mechanism of refractoriness and that this desensitization occurs as a result of interplay between leukotrienes and prostaglandins.
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| http://dx.doi.org/10.1016/j.iac.2013.02.004 | DOI Listing |
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