The development of a versatile method for the synthesis of spirocyclic pyrrolidinoindolines is discussed. Treatment of N-acyltryptamines with trifluoromethanesulfonic anhydride-2-chloropyridine reagent combination affords highly persistent spiroindoleninium ions that are subject to intra- and intermolecular addition at C2 by nucleophiles.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779471 | PMC |
| http://dx.doi.org/10.1021/ol401465y | DOI Listing |
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