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Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury.
EBioMedicine
October 2024
Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address:
Background: The inflammatory response in patients with traumatic brain injury (TBI) offers opportunities for stratification and intervention. Previous unselected approaches to immunomodulation in patients with TBI have not improved patient outcomes.
Methods: Serum and plasma samples from two prospective, multi-centre observational studies of patients with TBI were used to discover (Collaborative European NeuroTrauma Effectiveness Research [CENTER-TBI], Europe) and validate (Transforming Research and Clinical Knowledge in Traumatic Brain Injury [TRACK-TBI] Pilot, USA) individual variations in the immune response using a multiplex panel of 30 inflammatory mediators.
The investigation of diving accidents and fatalities.
Diving Hyperb Med
September 2024
Denver Office of the Medical Examiner, Denver, Colorado, United States of America.
Diving accidents result from a variety of causes including human error, inadequate health and fitness, environmental hazards and equipment problems. They usually involve a cascade of events resulting in the diver being injured or deceased. The accuracy and usefulness of a diving accident investigation relies on well-targeted interviews, good field investigation, evidence collection and preservation, and appropriate equipment assessment.
View Article and Find Full Text PDFOesophageal intubations in anaesthetic practice across Australia and New Zealand: A webAIRS analysis of 109 incidents.
Anaesth Intensive Care
September 2024
Department of Anaesthesia, Royal Adelaide Hospital, Adelaide, Australia.
Oesophageal intubations are more common than may be realised and can potentially cause significant patient harm even if promptly identified and corrected. Reports of morbidity due to unrecognised oesophageal intubation continue to present in coroner and media reports. Therefore, it would be helpful to identify mechanisms to prevent these events and implement strategies to avoid and identify incorrect endotracheal tube placement.
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