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| http://dx.doi.org/10.1111/cns.12140 | DOI Listing |
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Simultaneous activation of different subtypes of dopamine receptors may lead to activation of homeostatic sleep regulatory mechanisms.
Pharmacol Biochem Behav
January 2025
In vivo Electrophysiology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary. Electronic address:
Dopaminergic system gains importance in homeostatic sleep regulation, but the role of different dopamine receptors is not well-defined. 72 h rat electrocorticogram and sleep recordings were made after single application of dopaminergic drugs in clinical use or at least underwent clinical trials. The non-selective agonist apomorphine evoked short pharmacological sleep deprivation with intense wakefulness followed by pronounced sleep rebound.
View Article and Find Full Text PDFDopamine internalization via Uptake and stimulation of intracellular D-receptor-dependent calcium mobilization and CDP-diacylglycerol signaling.
Front Pharmacol
October 2024
Department of Biomedical Sciences, School of Medicine, City University of New York, New York, NY, United States.
Dopamine stimulates CDP-diacylglycerol biosynthesis through D-like receptors, particularly the D subtype most of which is intracellularly localized. CDP-diacylglycerol regulates phosphatidylinositol-4,5-bisphosphate-dependent signaling cascades by serving as obligatory substrate for phosphatidylinositol biosynthesis. Here, we used acute and organotypic brain tissues and cultured cells to explore the mechanism by which extracellular dopamine acts to modulate intracellular CDP-diacylglycerol.
View Article and Find Full Text PDFThe role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference.
Eur J Pharmacol
October 2024
Department of Physiology and Pharmacology, School of Basic Medical Sciences, Health Science Center, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang, 315211, PR China, Ningbo. Electronic address:
Article Synopsis
- The study investigates how the interaction between histamine H3 receptors (H3R) and dopamine D1 receptors (D1R) impacts the rewarding effects of Methamphetamine (METH).
- Mice experiments showed that blocking H3R with a specific antagonist (Thioperamide) reduced METH's rewarding effects, while an H1R antagonist (Pyrilamine) did not have similar results.
- The findings suggest that targeting the H3R-D1R complex could be a potential strategy for treating METH use disorder.
Caveolin-1, a Determinant of the Fate of MCF-7 Breast Cancer Cells.
Breast Cancer (Auckl)
January 2024
Department of Pathology, University of Virginia Health System, University of Virginia, Charlottesville, VA, USA.
Background: The scaffolding protein, caveolin-1 (Cav-1), participates in multiple cellular functions including promotion of sodium excretion from the kidney. Loss of expression of Cav-1 is associated with tumorigenesis of various types of cancer. We have shown the potential link between hypertension and breast cancer via abnormal function of the G protein-coupled receptor kinase type 4 (GRK4).
View Article and Find Full Text PDFThe dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions.
J Exp Clin Cancer Res
January 2024
Department of Blood Transfusion, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Background: Extensive local invasion of glioblastoma (GBM) cells within the central nervous system (CNS) is one factor that severely limits current treatments. The aim of this study was to uncover genes involved in the invasion process, which could also serve as therapeutic targets. For the isolation of invasive GBM cells from non-invasive cells, we used a three-dimensional organotypic co-culture system where glioma stem cell (GSC) spheres were confronted with brain organoids (BOs).
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