Background: Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones.
Materials And Methods: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS.
Result: Patients with MS had significantly lower testosterone, dehydroepiandrosterone sulfate and prolactin levels than controls in the follicular and luteal phase but lower estradiol levels only in the follicular phase. A positive correlation coefficient between follicle stimulating hormone and disease severity, and a reverse correlation with estradiol were found.
Conclusion: The hormone-related modulation of disease severity supports the suggestion that sex hormones play a role in MS disease.
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