PLoS One
Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America ; Translational Research Unit and Department of Molecular Pathology, Tokyo Medical University, Shinjuku, Tokyo, Japan.
Published: October 2017
p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis. While push, the Drosophila counterpart of p600, is dispensable for development up to adult stage, the role of p600 has not been studied during mouse development. Here we generated p600 knockout mice to investigate the in vivo functions of p600. Interestingly, we found that homozygous deletion of p600 results in lethality between embryonic days 11.5 and 13.5 with severe defects in both embryo and placenta. Since p600 is required for placental development, we performed conditional disruption of p600, which deletes selectively p600 in the embryo but not in the placenta. The conditional mutant embryos survive longer than knockout embryos but ultimately die before embryonic day 14.5. The mutant embryos display severe cardiac problems characterized by ventricular septal defects and thin ventricular walls. These anomalies are associated with reduced activation of FAK and decreased expression of MEF2, which is regulated by FAK and plays a crucial role in cardiac development. Moreover, we observed pleiotropic defects in the liver and brain. In sum, our study sheds light on the essential roles of p600 in fetal development.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688873 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066269 | PLOS |
Cogn Neurodyn
December 2024
Department of Language Science and Technology, Saarland University, Saarbrücken, Germany.
Theories of the electrophysiology of language comprehension are mostly informed by event-related potential effects observed between condition averages. We here argue that a dissociation between competing effect-level explanations of event-related potentials can be achieved by turning to predictions and analyses at the single-trial level. Specifically, we examine the single-trial dynamics in event-related potential data that exhibited a biphasic N400-P600 effect pattern.
View Article and Find Full Text PDFHeliyon
December 2024
Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, 121205, Moscow, Russia.
Mental imagery is a crucial cognitive process, yet its underlying neural mechanisms remain less understood compared to perception. Furthermore, within the realm of mental imagery, the somatosensory domain is particularly underexplored compared to other sensory modalities. This study aims to investigate the influence of tactile imagery (TI) on cortical somatosensory processing.
View Article and Find Full Text PDFJ Cardiovasc Electrophysiol
December 2024
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Introduction: Atrial pacing maps are often used as substitutes for sinus rhythm (SR) maps to expedite mapping procedures. However, the impact of this method on electrophysiological parameters has not been systematically examined. This study aimed to elucidate the advantages and limitations of atrial pacing maps.
View Article and Find Full Text PDFComput Biol Med
December 2024
Know Center Research GmbH, Graz, Austria; Institute of Interactive Systems and Data Science, Graz University of Technology, Graz, Austria.
Augmented Reality (AR) technologies enhance the real world by integrating contextual digital information about physical entities. However, inconsistencies between physical reality and digital augmentations, which may arise from errors in the visualized information or the user's mental context, can considerably impact user experience. This work characterizes the brain dynamics associated with processing incongruent information within an AR environment.
View Article and Find Full Text PDFNeurosci Lett
November 2024
Department of Linguistics, University of Kansas, United States.
This study compares the processing of cleft structures against that of monoclausal sentences using event-related potential (ERP). We aim to understand how syntactic complexity is processed by comparing the neural response to cleft and single-clause sentences with identical verb phrases, controlling for verb bias frequency effects. Sixty participants were tested, and we presented 100 cleft and 100 monoclausal sentences, balanced for active and passive verb usage.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.