[The state of the microsomal oxidative system in the rat liver during fecal peritonitis].

Content and activity of cytochrome P-450, activity of main microsomal enzymes as well as content of glycogen, lactic and pyruvic acids were studied in liver tissue of rats within 24, 48 and 72 hrs after simulation of acute fecal peritonitis. Inhibition of the enzymatic activity of microsomal oxidative system correlated with hypoxia which developed in liver tissue within all the periods of acute fecal peritonitis studied. At the same time, catalytic activity of cytochrome P-450 was increased towards substrates of the I and II types. Endotoxemia and hypoxia of liver tissue, resulting in activation of phospholipases, appear to be mainly responsible for inhibition of microsomal enzymes activity in liver tissue under conditions of acute peritonitis.