Polypeptide preparation thymalin obtained from thymus was found to normalize the LDH isoenzyme spectrum and cyclase system in lymphocytes of patients. Thymalin contributed also to expression of differentiation antigens on T-lymphocytes surface. As a result of this functional activity of T-lymphocytes was restored, which correlated with improvement of the patients clinical state. Biochemical and immunological patterns of lymphocytes differentiation may be used both in diagnosis and control of treatment efficiency in patients with acquired immunodeficiency syndrome.
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