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State of energy metabolism was studied in brain of rats at agonal steps caused by bleeding during severe and long-term hypotension (30 mmHg, up to 30 hrs). Fast loss of high energy-containing phosphates, cell energy potential of adenine nucleotides and an increase in the lactate/pyruvate ratio were found in non-resistant rats. At the same time, in the most resistant rats normal content of creatine phosphate, ATP was maintained; energy potential was unaltered and anaerobic glycolysis was not activated. Content of glucose and glycogen did not alter considerably in all the animals studied.
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