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Minimally Invasive Approach to Treating Moderate Dental Fluorosis: A Case Report.
Cureus
November 2024
Conservative Dentistry, Universiti Sains Malaysia, Kota Bharu, MYS.
Dental fluorosis (DF) is a condition affecting tooth enamel that occurs during the development of permanent teeth, resulting from excessive fluoride consumption. Based on the severity, the tooth surface exhibits discoloration or structural anomalies. The range of colors varies from mild discoloration to severe dark brown lesions.
View Article and Find Full Text PDFThe Rate of Postoperative Bile Leak in Minimally Invasive Liver Resection in Comparison With Open Surgery: A Systematic Review.
Cureus
November 2024
General Surgery, University Hospitals of Leicester NHS Trust, Leicester, GBR.
The rapid advances in laparoscopic surgery have meant that formerly complex techniques are now commonly performed via this method. These practices are now becoming increasingly popular in the discipline of hepatopancreaticobiliary (HPB) surgery. One such example is liver resection, which is the focus of our review.
View Article and Find Full Text PDFMultiphysics modelling of the impact of skin deformation and strain on microneedle-based transdermal therapeutic delivery.
Acta Biomater
December 2024
UCD Centre for Biomedical Engineering, University College Dublin, Belfield, Dublin 4, Ireland; School of Mechanical & Materials Engineering, University College Dublin, Belfield, Dublin 4, Ireland; UCD Charles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland; The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. Electronic address:
Microneedle patches (MNs) hold enormous potential to facilitate the minimally-invasive delivery of drugs and vaccines transdermally. However, the micro-mechanics of skin deformation significantly influence the permeation of therapeutics through the skin. Previous studies often fail to appreciate the complexities in microneedle-skin mechanical interactions.
View Article and Find Full Text PDFSynovial fluid extracellular vesicles as arthritis biomarkers: the added value of lipid-profiling and integrated omics.
Extracell Vesicles Circ Nucl Acids
June 2024
Division Cell Biology, Metabolism & Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584 CM, the Netherlands.
Arthritis, a diverse group of inflammatory joint disorders, poses great challenges in early diagnosis and targeted treatment. Timely intervention is imperative, yet conventional diagnostic methods are not able to detect subtle early symptoms. Hence, there is an urgent need for specific biomarkers that discriminate between different arthritis forms and for early diagnosis.
View Article and Find Full Text PDFNovel minimally invasive irrigating catheter approach for subdural empyema: a case report.
Br J Neurosurg
December 2024
Department of Neurosurgery, Mount Sinai Hospital, New York, NY, USA.
Objective: To present a new technique for the management of subdural empyema to promote resolution and prevent recurrence.
Background: Classic treatment for subdural empyema (SDE) has consisted of antibiotics and surgical treatment with either craniotomy or burrholes. There are still several complications that persist after current treatment, including relatively high rates of morbidity and mortality.
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