Antimycobacterial effects of thiosemicarbazones were discovered in the late 1940s. The best known representative of these compounds is thioacetazone that has been used in the therapy of tuberculosis since the turn of the 1940s and 1950s. At present, it is used only rarely since it exhibits severe side effects. This paper deals with the antimycobacterial effects of thiosemicarbazones and N,N-dimethylthiosemicarbazones derived from 5-alkyl-2-acetylpyrazines. Some of these compounds displayed high inhibition of the growth of Mycobacterium tuberculosis H37Rv, but were excluded from the in vivo studies due to their cytotoxic effects. Nonetheless, they can be used as model compounds for studying the mechanisms of antimycobacterial action of thiosemicarbazones.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A rare case of culture-negative infective endocarditis following cataract surgery.
J Int Med Res
January 2025
Colombo South Teaching Hospital, Colombo, Sri Lanka.
A 70-year-old man developed intermittent fever with chills, severe anorexia, generalized weakness, and mild exertional difficulty in breathing following posterior chamber intraocular lens replacement surgery for a mature white cataract in the left eye. Laboratory tests revealed persistent negative blood cultures, normocytic and normochromic anemia, neutrophilia, and elevated inflammatory markers despite multiple courses of antibiotics. All other investigations conducted to identify the cause of prolonged fever, including transthoracic echocardiography, were negative.
View Article and Find Full Text PDFRisks of anti- therapy and long-term therapy with antisecretory drugs.
World J Gastroenterol
January 2025
Department of Therapy, North Caucasus State Academy, Cherkessk 369000, Russia.
() infection has a protective effect on gastroesophageal reflux disease (GERD). Both of these diseases have a very high incidence and prevalence. As a result, GERD often recurs after anti- therapy.
View Article and Find Full Text PDFAdvances in gastrointestinal vascular bleeding disorders: Successful sirolimus treatment in colonic angioectasia.
World J Gastroenterol
January 2025
Department of Gastroenterology, Air Force Medical Center, Beijing 100142, China.
Background: Gastrointestinal (GI) vascular bleeding disorders pose significant clinical challenges due to their complex pathogenesis and varied treatment responses. Despite advancements in diagnostic and therapeutic techniques, optimal management strategies remain elusive, necessitating further research.
Aim: To assess research trends and clinical advancements in GI vascular bleeding disorders, highlighting key themes and therapeutic progress.
In-vitro susceptibility of pathogenic and intermediate Leptospira species towards antibiotics and herb extracts.
Trop Biomed
December 2024
Resource Biotechnology Programme, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia.
Leptospirosis is a severe and potentially fatal re-emerging zoonotic and waterborne disease caused by pathogenic and intermediate species of Leptospira. Given the high global rates of morbidity and mortality associated with this disease, there is an urgent need to explore alternative therapeutic agents to enhance treatment options. This study investigates the anti-leptospiral efficacy of several common antibiotics-penicillin G, doxycycline, ampicillin, amoxicillin, cefotaxime, chloramphenicol, and erythromycin, as well as extracts from local herbs, Hydnophytum formicarum Jack and Boesenbergia stenophylla, against pathogenic and intermediate Leptospira strains.
View Article and Find Full Text PDFAntibacterial and antibiofilm properties of Helix aspersa mucus towards multidrug resistant Staphylococcus aureus.
Trop Biomed
December 2024
Laboratory of Microbiology and Molecular Biology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria.
The increasing prevalence of multidrug-resistant bacteria necessitates the exploration of novel antimicrobial agents. This study aims to investigate the antibacterial and antibiofilm properties of mucus from Helix aspersa, a species of terrestrial snail, against multidrug resistant Staphylococcus aureus strains. The antibacterial effect was assessed using well diffusion, microdilution, and time kill assays.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!