We have studied the effect of time dependent magnetic field on the barrier crossing dynamics of a charged particle. An interplay of the magnetic field induced electric field and the applied field reveals several interesting features. For slowly oscillating field the barrier crossing rate increases remarkably particularly at large amplitude of the field. For appreciably large frequency a generically distinct phenomenon appears by virtue of parametric resonance manifested in multiple peaks appearing in the variation of the mean first passage time as a function of the amplitude. The parametric resonance is more robust against the variation of amplitude of the oscillating field compared to the case of variation of frequency. The barrier crossing time of a particle can be tuned para-metrically by appropriate choice of amplitude and frequency of the oscillating magnetic field.
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http://dx.doi.org/10.1063/1.4811363 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, China.
CRISPR/Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing technology represents great promise for treating glioblastoma (GBM) due to its potential to permanently eliminate tumor pathogenic genes. Unfortunately, delivering CRISPR to the GBM in a safe and effective manner is challenging. Herein, a glycosylated and cascade-responsive nanoparticle (GCNP) that can effectively cross the blood-brain barrier (BBB) and activate CRISPR/Cas9-based gene editing only in the GBM is designed.
View Article and Find Full Text PDFDisabil Rehabil Assist Technol
January 2025
School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, Ohio, USA.
The wheelchair service delivery process (SDP) is a large complex system and therefore has many potential points of failure; determining priorities for improvement is challenging. The complexities introduce several barriers to accessing and maintaining wheelchairs for individuals with mobility impairments. Given the breadth and depth of the barriers, it is important to know in which areas to focus future policy reform efforts.
View Article and Find Full Text PDFBMJ Open Qual
December 2024
School of Medicine, Saint Joseph University School of Medical Science, Beirut, Lebanon.
Objective: The aim of this study is to identify the key barriers that prevent medication administration errors (MAEs) from being reported by nurses in Lebanese hospitals.
Methods: A quantitative cross-sectional study was conducted at Hotel-Dieu de France Hospital using a self-administered questionnaire. A total of 275 responses were recorded and analysed using the IBM SPSS software V.
J Vet Intern Med
January 2025
School of Veterinary Science, Massey University, Palmerston North, New Zealand.
Background: Most veterinary literature examining medication compliance has described the phenomenon in dogs. The evidence available regarding factors affecting cat owner medication compliance is limited.
Objectives: Identify and describe factors associated with cat owners' noncompliance with veterinary recommendations for pet medications, as well as client-reported barriers and aids to administering medications prescribed by primary care veterinarians.
Adv Mater
January 2025
Liquid Crystals and Photonics Group, Department of Electronics and Information Systems, Ghent University, Technologiepark-Zwijnaarde 126, Ghent, 9052, Belgium.
In liquid crystal (LC) cells, the surface patterning directs the self-assembly of the uniaxial building blocks in the bulk, enabling the design of stimuli-response optical devices with various functionalities. The combination of different anchoring patterns at both substrates can lead to surface induced frustration, preventing a purely planar and defect-free configuration. In cells with crossed assembly of rotating anchoring patterns, elastic deformations allow to obtain a defect-free bulk configuration, but an electrical stimulus can induce disclination lines.
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