AI Article Synopsis
- Klotho is an anti-aging protein that impacts lifespan by regulating longevity pathways like insulin/IGF1 and Wnt signaling.
- Decreased levels of Klotho are linked to normal aging, with potential causes including increased methylation of its promoter and microRNA influences.
- Specific microRNAs like microRNA-339 and microRNA-556 can reduce Klotho expression, suggesting that their regulation might play a part in both aging and cancer development.
Article Abstract
Klotho is an anti-aging protein with direct effects on life-span in mice. Klotho functions to regulate pathways classically associated with longevity including insulin/IGF1 and Wnt signaling. Decreased Klotho protein expression is observed throughout the body during the normal aging process. While increased methylation of the Klotho promoter is reported, other epigenetic mechanisms could contribute to age-related downregulation of Klotho expression, including microRNA-mediated regulation. Following in silico identification of potential microRNA binding sites within the Klotho 3' untranslated region, reporter assays reveal regulation by microRNA-339, microRNA-556, and, to a lesser extent, microRNA-10 and microRNA-199. MicroRNA-339 and microRNA-556 were further found to directly decrease Klotho protein expression indicating that, if upregulated in aging tissue, these microRNA could play a role in age-related downregulation of Klotho messenger RNA. These microRNAs are differentially regulated in cancer cells compared to normal cells and may imply a role for microRNA-mediated regulation of Klotho in cancer.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889880 | PMC |
| http://dx.doi.org/10.1007/s11357-013-9555-6 | DOI Listing |
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MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.
Age (Dordr)
February 2014
Department of Neurobiology, University of Alabama at Birmingham, 1825 University Blvd, Shelby Building 913, Birmingham, AL, 35294, USA.
Article Synopsis
- Klotho is an anti-aging protein that impacts lifespan by regulating longevity pathways like insulin/IGF1 and Wnt signaling.
- Decreased levels of Klotho are linked to normal aging, with potential causes including increased methylation of its promoter and microRNA influences.
- Specific microRNAs like microRNA-339 and microRNA-556 can reduce Klotho expression, suggesting that their regulation might play a part in both aging and cancer development.
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