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Ecological insights into the microbiology of food using metagenomics and its potential surveillance applications.
Microb Genom
January 2025
Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.
A diverse array of micro-organisms can be found on food, including those that are pathogenic or resistant to antimicrobial drugs. Metagenomics involves extracting and sequencing the DNA of all micro-organisms on a sample, and here, we used a combination of culture and culture-independent approaches to investigate the microbial ecology of food to assess the potential application of metagenomics for the microbial surveillance of food. We cultured common foodborne pathogens and other organisms including , spp.
View Article and Find Full Text PDFSystems-level liquid biopsy in advanced prostate cancer.
Endocr Relat Cancer
January 2025
S Dehm, Masonic Cancer Center, University of Minnesota, Minneapolis, United States.
Treatment for castration-resistant prostate cancer (CRPC) primarily involves the suppression of androgen receptor (AR) activity using androgen receptor signaling inhibitors (ARSIs). While ARSIs have extended patient survival, resistance inevitably develops. Mechanisms of resistance include genomic aberrations at the AR locus that reactivate AR signaling, or lineage plasticity that drives emergence of AR-independent phenotypes.
View Article and Find Full Text PDFBalancing landscape values and tourism choices: Integrating participatory mapping and the IPBES Values Typology.
Ambio
January 2025
Department of Geography and Geology, University of Turku, 20014, Turku, Finland.
The United Nations Educational, Scientific and Cultural Organization (UNESCO) Biosphere Reserves aim to balance nature and human coexistence, but increasing tourism challenges landscape management. The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) stresses the importance of understanding stakeholder values for effective management of natural spaces through a typology of intrinsic, instrumental, and relational values. This study applies this IPBES typology to tourism preferences in the Archipelago Sea Biosphere Reserve (ABR) using Public Participation Geographic Information Systems (PPGIS).
View Article and Find Full Text PDFBeyond the Nest: The Role of Financial Independence in Young Adult Health.
Int J Behav Med
January 2025
Department of Psychology, Georgia State University, 140 Decatur Street, Suite 1150 Urban Life Building, Atlanta, GA, 30303, USA.
Background: This study aimed to examine the impact of neighborhood conditions and household material hardship experiences on young adult health outcomes, while also considering financial autonomy as a critical determinant of health.
Method: We employed a cross-sectional observational design with a diverse sample of young adults from a large urban university. Structural equation modeling was used to analyze the relationships between neighborhood conditions and material hardship with health outcomes by financial autonomy.
Exploring Benzo[d]thiazol-2-Amine Derivatives, Synthesis, and Molecular Docking Insights Potential Anticancer Agents Targeting HER Enzyme and DNA.
Appl Biochem Biotechnol
January 2025
Department of Chemistry, College of Science, University of Diyala, Baquba, Diyala, Iraq.
The synthesis and characterization of benzo[d]thiazol-2-amine derivatives, which were prepared by reacting benzothiazole with para-aminobenzophenone in ethanol, supplemented with glacial acetic acid. Subsequently, compound (2) was synthesized from compound (1) using NaNO, HPO, and HNO in a water-based solvent, resulting in 2-hydroxy-1-naphthaldehyde. Another derivative, compound (3), was synthesized by reacting compound (1) with vanillin under similar conditions.
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