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Dynamic perioperative platelet activity and cardiovascular events in peripheral artery disease.
J Vasc Surg
October 2024
Leon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York, NY; Division of Vascular and Endovascular Surgery, Department of Surgery, NYU Langone Health and Manhattan Veterans Affairs Hospital, New York, NY. Electronic address:
Objective: Patients with peripheral artery disease (PAD) undergo lower extremity revascularization (LER) for symptomatic relief or limb salvage. Despite LER, patients remain at increased risk of platelet-mediated complications, such as major adverse cardiac and limb events (MACLEs). Platelet activity is associated with cardiovascular events, yet little is known about the dynamic nature of platelet activity over time.
View Article and Find Full Text PDFRyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure.
J Mol Cell Cardiol
May 2023
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.
Background: Dantrolene binds to the Leu-Cys region of the N-terminal domain of cardiac ryanodine receptor (RyR2), which corresponds to the Leu-Cys region of the skeletal ryanodine receptor, and suppresses diastolic Ca leakage through RyR2.
Objective: We investigated whether the chronic administration of dantrolene prevented left ventricular (LV) remodeling and ventricular tachycardia (VT) after myocardial infarction (MI) by the same mechanism with the mutation V3599K of RyR2, which indicated that the inhibition of diastolic Ca leakage occurred by enhancing the binding affinity of calmodulin (CaM) to RyR2.
Methods And Results: A left anterior descending coronary artery ligation MI model was developed in mice.
Myocardial stunning secondary to erroneous administration of intravenous epinephrine.
SAGE Open Med Case Rep
March 2023
Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Epinephrine is a commonly used medication for emergent conditions, such as anaphylaxis, respiratory distress, and shock. However, its versatility can also lead to iatrogenic errors in dosages, concentrations, and routes of administration. In this case, a 47-year-old female experiencing anaphylaxis received an intravenous dose of 0.
View Article and Find Full Text PDFModulatory effect of Ovothiol-A on myocardial infarction induced by epinephrine in rats.
J Food Biochem
September 2022
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Myocardial infarction (MI) is one of the most prevalent disorders seen in clinical practice, and its prevalence has risen dramatically in the last decade. Ovothiol-A is a natural product isolated from sea urchin eggs and display unusual antioxidant properties. The present study investigates the therapeutic effect of Ovothiol-A against MI stimulated in rats by epinephrine injection.
View Article and Find Full Text PDFCircadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation.
Eur Heart J
June 2022
Division of Cardiology, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai, China.
Aims: Adverse cardiovascular events have day/night patterns with peaks in the morning, potentially related to endogenous circadian clock control of platelet activation. Circadian nuclear receptor Rev-erbα is an essential and negative component of the circadian clock. To date, the expression profile and biological function of Rev-erbα in platelets have never been reported.
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