Two new cycloartane triterpene glycosides (compounds 1 and 4) were isolated from the whole plants of Beesia calthaefolia with two known glycosides (compounds 2 and 3). Compounds 1 and 4 were assigned as (20S(*),24R(*))-16β-acetoxy-20, 24-epoxy-9, 19-cyclolanostane-3β,12β,15α,18,25-pentaol-3-O-β-d-xylopyranoside and (20S(*),24 R(*))-16β-acetoxy-20,24-epoxy-9,19-cyclolanostane-3β,15α,18,25-tetraol-3-O-β-d-xylopyranoside, respectively. Their structures were elucidated on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. Compounds 1 and 4 showed potential inhibition activity for the proliferation of splenocytes.
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http://dx.doi.org/10.1080/14786419.2013.811407 | DOI Listing |
Planta Med
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied . To explore the phytochemical profile of for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with a tandem mass spectrometry-based method to identify cycloartane-type triterpenes. Eventually, five new cycloartane-type triterpenoids, adsurgosides A - D ( 1 - 4: ) and 3-methyl-3,4-seco-cyclostellanol (5: ), together with two known analogs, cycloastragenol (6: ) and cyclopycanthogenin (7: ), were isolated from the roots of .
View Article and Find Full Text PDFPhytochemistry
February 2025
Natural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address:
Nine previously undescribed (1-9) and seven known (10-16) cycloartane-type triterpenoids were isolated and characterized from Combretum quadrangulare Kurz using physicochemical and spectroscopic methods. The absolute configurations of these compounds were determined through modified Mosher's method and quantum chemical calculation of electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Their inhibitory activities against PCSK9 secretion were assessed, and a plausible structure-activity relationship was delineated.
View Article and Find Full Text PDFPlanta Med
January 2025
Near East University, Faculty of Pharmacy, Department of Pharmacognosy, Lefkoşa (Nicosia), TRNC, Mersin-10, Turkey.
is a widespread genus comprising approximately 3500 species, both annual and perennial, found across Asia, Europe, Africa, and the Americas. In Turkey, it is represented by 63 sections and 485 taxa with a high endemism ratio (51%). In traditional medicine, the roots of various species represent very old and well-known drugs used for antiperspirant, diuretic, and tonic purposes, as well as for the treatment of nephritis, diabetes, leukemia, and uterine cancer.
View Article and Find Full Text PDFJ Nat Prod
November 2024
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.
Int J Mol Sci
July 2024
State Key Laboratory of Green Pesticide, South China Agricultural University, Guangzhou 510642, China.
Plants of the Meliaceae family have long attracted researchers' interest due to their various insecticidal activities, with triterpenes being the main active ingredients. In this paper, we discuss triterpenoids with insecticidal activity from insecticidal plant species of genera (, , , , , , , , , , , , , , and ) in the family Meliaceae. Among these genera, deserves further research, with twelve species possessing insecticidal activity.
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