We retrospectively studied 22 patients with catheter-related candidemia caused by Candida albicans. Strains isolated simultaneously from blood and catheter tips were genotyped using six microsatellite markers. Matches between genotypes of isolates recovered from both sample sources were found in 20/22 (91%) patients. Consequently, identification of the same species from both the catheter tip and blood could be used to confirm catheter-related candidemia.
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http://dx.doi.org/10.3109/13693786.2013.803165 | DOI Listing |
Planta
January 2025
ICAR-National Institute for Plant Biotechnology, New Delhi, 110012, Delhi, India.
Small RNA sequencing analysis in two chickpea genotypes, JG 62 (Fusarium wilt-susceptible) and WR 315 (Fusarium wilt-resistant), under Fusarium wilt stress led to identification of 544 miRNAs which included 406 known and 138 novel miRNAs. A total of 115 miRNAs showed differential expression in both the genotypes across different combinations. A miRNA, Car-miR398 targeted copper chaperone for superoxide dismutase (CCS) that, in turn, regulated superoxide dismutase (SOD) activity during chickpea-Foc interaction.
View Article and Find Full Text PDFMol Genet Genomics
January 2025
Department of Botany, Biology Institute, UnB, Brasília, DF, 70910-900, Brazil.
Precursors of microRNAs (pre-miRNAs) are less used in silico to mine miRNAs. This study developed PmiR-Select based on covariance models (CMs) to identify new pre-miRNAs, detecting conserved secondary structural features across RNA sequences and eliminating the redundancy. The pipeline preceded PmiR-Select filtered 20% plant pre-miRNAs (from 38589 to 8677) from miRBase.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Centre de Recherche Scientifique Et Technique en Analyses Physico-Chimiques, CP 42004, Bou-Ismail, Tipaza, Algeria.
ZnO-CoO material was successfully synthesized by the co-precipitation method and used as a catalyst for the removal of diclofenac sodium (DCF). ZnO-CoO exhibited higher catalytic activity in the catalytic process compared to the photocatalytic processes. Under optimum conditions, the activation of peroxymonosulfate (PMS) by ZnO-CoO achieved approximately 99% removal of DCF, confirming the effective adsorption and activation of PMS.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University, New York, NY, USA.
Background: At least one-third of the identified risk alleles from Genome Wide Association Studies of Alzheimer's disease (AD) are involved in lipid metabolism, lipid transport, or direct lipid binding. BIN1 which is also known as Amphiphysin 2; and PICALM which are involved in phosphoinositide metabolism and binding rank just below the highest risk gene variant of Apolipoprotein E (ApoEε4), a cholesterol and phospholipid transporter. In addition to genetic variants, lipidomic studies have reported severe metabolic dysregulation in human autopsy brain tissue, CSF, blood and multiple mouse models of AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland, OH, USA.
Background: The emerging tools of protein-protein interactome network offer a platform to explore not only the molecular complexity of human diseases, but also to identify risk genes and drug targets. Integration of the genome, transcriptome, proteome, and the interactome networks are essential for such identification, including Alzheimer's disease (AD), Parkinson disease (PD), and Amyotrophic lateral sclerosis (ALS) METHOD: In this study, we performed multi-modal analyses of cross-species protein interactome networks and human brain functional genomics data to identify risk genes and drug targets for neurodegenerative diseases. We presented a multi-view topology-based deep learning framework to identify disease-associated genes for cross-species interactome (TAG-X).
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