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Barriers to PrEP use and adherence among adolescent girls and young women in Eastern, Southern, and Western Africa: a scoping review.
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Department of Public Health Institute of Tropical Medicine, Antwerp, Belgium.
Background: Adolescent girls and young women (AGYW) are disproportionately affected by HIV. Globally, in 2022, an estimated 4000 AGYW 15-24 were newly infected with HIV weekly, and nearly 78% of these infections occurred in sub-Saharan Africa. Oral Pre-Exposure Prophylaxis (PrEP) is a key HIV prevention option within an overall HIV combination prevention approach with an efficacy of over 90% when taken correctly.
View Article and Find Full Text PDFRhino-orbital-cerebral mucormycosis in acute myeloid leukemia patients: a case series from Sri Lanka.
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National Cancer Institute, Maharagama, Sri Lanka.
Background: Mucormycosis, is a rare yet potentially life-threatening fungal infection common in immunocompromised patients. Despite optimal care, mucormycosis in haemato-oncological patients often results in poor outcomes. This case series details the presentations and unique challenges faced during the management of patients with acute myeloid leukemia who developed rhino-cerebral mucormycosis.
View Article and Find Full Text PDFDifferent phenotypes of hypertension and associated cardiovascular and all-cause mortality: a systematic review and meta-analysis.
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Department of Internal Medicine, HIND Institute of Medical Sciences, Barabanki, India.
Background: Hypertension is a leading cause of premature mortality and morbidity. Recent guidelines advocate for out-of-office blood pressure monitoring, including ambulatory and home BP monitoring, to better identify hypertension phenotypes like masked hypertension, white coat hypertension, and sustained hypertension. However, clinical inertia persists due to a lack of robust evidence on the effectiveness of screening these phenotypes and their association with cardiovascular and all-cause mortality.
View Article and Find Full Text PDFOutcome Measures after Peripheral Nerve Injury: Past, Present and Future.
J Hand Surg Asian Pac Vol
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Washington University School of Medicine, St Louis, MO, USA.
Peripheral nerve injuries (PNI) present substantial challenges due to variability in injury severity and limited regenerative capabilities. Historically, PNI research has focussed on measures such as subjective surgeon outcome grading, two-point discrimination (2PD) and the Medical Research Council (MRC) grading system. While these methods have use, there are also limitations related to subjectivity and sensitivity.
View Article and Find Full Text PDFQuantifying and Assessing Cleaning and Disinfection Residues.
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Cell and Gene Therapy Operations Manager, HiTech Health.
Joint presentation - Ecolab and HiTech Health (CDMO for CGT)The purpose of this presentation is to review the impact cleaning and disinfectant residues can present to an ATMP cGMP manufacturing facility and discuss how to assess and manage these residues.The term "disinfectant residue" can illicit different responses. For some, they pose a risk potential product contamination, or can alternatively be seen as evidence that cleaning and disinfection has been performed.
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