Purpose: Articular stepoffs that occur after fracture and are greater in size than the thickness of the articular surface seem to result in arthritis. The thickness of a joint's cartilage may, therefore, set the limit for acceptable stepoff when treating fractures. The goal of our study was to determine the thickness of the articular cartilage at the distal radius.
Methods: We conducted a cadaveric study of 19 wrists to measure the thickness of cartilage at the distal radius. After harvest, we made multiple slices of each radius and used a standardized technique to directly measure the articular cartilage in the scaphoid and lunate fossae and along the interfossal ridge.
Results: The average cartilage thickness in our cohort was 0.6 mm. The average articular surface thickness was < 1 mm in all measured areas (scaphoid fossa, 0.7 mm; interfossal ridge, 0.8 mm; lunate fossa, 0.6 mm). Among the samples, 98% had an average thickness of < 1 mm. The maximum recorded thickness was 1.1 mm.
Conclusions: Our study quantifies the thickness of the articular cartilage at the distal radius. Our finding of cartilage thicknesses of < 1 mm is consistent with multiple clinical studies, suggesting that stepoffs of > 1 mm result in radiographic signs of arthritis. This provides further evidence linking the thickness of articular cartilage to radiographic outcomes and, possibly, clinical outcomes.
Clinical Relevance: Our findings provide anatomic support for using 1 mm or less as an acceptable articular stepoff size in the treatment of fractures of the distal radius.
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http://dx.doi.org/10.1016/j.jhsa.2013.04.037 | DOI Listing |
J Mol Med (Berl)
January 2025
Department of Orthopedics, The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital), Weifang, 261000, China.
Osteoarthritis (OA) is a common degenerative bone and joint disease with an unclear pathogenesis. Our study identified that the histone acetyltransferase encoded by Kat7 is upregulated in the affected articular cartilage of OA patients and in a mice model of medial meniscal instability-induced OA. Chondrocyte-specific knockdown of Kat7 expression exhibited a protective effect on articular cartilage integrity.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Regenerative Medicine and Stem Cell Laboratory (RMS), Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502 284, Telangana, India.
Despite advancements in chronic arthritis treatment, there remains a significant demand for advanced nanotechnologies capable of efficiently delivering a wide range of therapeutic agents to provide symptomatic relief and facilitate the healing of inflamed cartilage tissue. Considering the significant impact of hypoxia on the development and maintenance of chondral tissue, replicating its effects on stem cells could be a potential approach for the treatment of osteoarthritis (OA). Cobalt is a prominent hypoxia-inducing agent, owing to its ability to activate the hypoxia-inducible factor (HIF) pathway regardless of cellular oxygen levels.
View Article and Find Full Text PDFRadiology
January 2025
From the Department of Radiology, Division of Musculoskeletal Radiology, NYU Grossman School of Medicine, 660 1st Ave, 3rd Fl, Rm 313, New York, NY 10016 (S.S.W., J.V., R.K., E.H.P., J.F.); Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, University Hospital Tübingen, Tübingen, Germany (S.S.W.); Department of Radiology, University Hospital Basel, Basel, Switzerland (J.V.); Department of Radiology, Hospital do Coraçao, São Paulo, Brazil (T.C.R.); Academic Surgical Unit, South West London Elective Orthopaedic Centre (SWLEOC), London, United Kingdom (D.D.); Department of Radiology, Balgrist University Hospital, Zurich, Switzerland (B.F.); Department of Radiology, Jeonbuk National University Hospital, Jeonju, Republic of Korea (E.H.P.); Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea (E.H.P.); Medscanlagos Radiology, Cabo Frio, Brazil (A.S.); Centre for Data Analytics, Bond University, Gold Coast, Australia (S.E.S.); Siemens Healthineers AG, Erlangen, Germany (I.B.); and Siemens Medical Solutions USA, Malvern, Pa (G.K.).
Background Deep learning (DL) methods can improve accelerated MRI but require validation against an independent reference standard to ensure robustness and accuracy. Purpose To validate the diagnostic performance of twofold-simultaneous-multislice (SMSx2) twofold-parallel-imaging (PIx2)-accelerated DL superresolution MRI in the knee against conventional SMSx2-PIx2-accelerated MRI using arthroscopy as the reference standard. Materials and Methods Adults with painful knee conditions were prospectively enrolled from December 2021 to October 2022.
View Article and Find Full Text PDFJ Dent Sci
January 2025
Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Background/purpose: In this study, we utilized magnetic resonance imaging data of the temporomandibular joint, collected from the Division of Oral and Maxillofacial Surgery at Taipei Veterans General Hospital. Our research focuses on the classification and severity analysis of temporomandibular joint disease using convolutional neural networks.
Materials And Methods: In gray-scale image series, the most critical features often lie within the articular disc cartilage, situated at the junction of the temporal bone and the condyles.
Cureus
December 2024
Orthopaedics and Traumatology, Unidade Local de Saúde de Viseu Dão-Lafões, Viseu, PRT.
Reverse Hill-Sachs lesions (RHSL) are common complications associated with posterior shoulder dislocations and represent a significant challenge for preserving joint stability and function. If untreated, these compression fractures of the anteromedial humeral head can compromise the integrity of the joint, predisposing patients to recurrent instability and arthropathy. While various treatment modalities exist, achieving an anatomic reduction of the defect while preserving the articular cartilage remains a desirable outcome, particularly in acute settings.
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