AI Article Synopsis
- Did you know that exercise can really help kids with cystic fibrosis (CF)? It’s key to understand how their bodies use energy during workouts to help them eat right and stay active!* * In a study, boys with CF showed significantly lower fat oxidation rates during cycling compared to healthy controls, suggesting that their bodies struggle to use fat for energy effectively.* * The findings indicate that while kids with CF rely more on carbohydrates for energy during exercise, they have difficulty mobilizing free fatty acids, which could impact their overall energy use and nutrition needs.*
Article Abstract
Background: Exercise is a viable form of therapy for children with cystic fibrosis (CF). Understanding the energy sources used during exercise would aid CF patients in obtaining proper nutrition in order to sustain an active lifestyle.
Methods: Six boys with CF (mean age ± SD: 14.8 ± 2.3 yrs, FEV1: 99 ± 18% predicted) and six matched controls (14.0 ± 2.2 yrs) completed a session of two 30 min bouts of cycling at an intensity set at 50% peak mechanical power. Rates of total fat and carbohydrate (CHO) oxidation were calculated from expired gases. Plasma insulin, glucose and free fatty acid (FFA) were determined before, during and at the end of the exercise.
Results: Rates of fat oxidation (expressed in mean mg × kg body weight(-1) × min(-1) ± SD) were significantly lower in children with CF (5.7 ± 1.6) compared to controls (8.6 ± 1.8, p < 0.05). Children with CF also had lower values than controls in amount of fat oxidized (CF: 17.3 ± 5.0 g, controls: 26.1 ± 5.9 g, p < 0.05) and percent of total energy expenditure from fat (CF: 32 ± 6%, controls: 43 ± 7%, p < .0.05), but a higher contribution from CHO (CF: 68 ± 6%, controls: 57 ± 7% p < .0.05). Plasma FFA was significantly lower in children with CF compared to controls during (CF: 252.5 ± 117.9 μM, controls: 602.2 ± 295.6) and at the end of exercise (CF: 430.9 ± 180.6, controls: 1147.5 ± 473.5). There were no differences in the rates of CHO oxidation, insulin or glucose between groups.
Conclusion: Fat metabolism during exercise is impaired in boys with CF and may be attributed to an inability to mobilize FFA.
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| http://dx.doi.org/10.1016/j.jcf.2013.05.014 | DOI Listing |
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